208d: Difference between revisions

From Proteopedia
Jump to navigationJump to search
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,328,572 edits
New page: left|200px<br /><applet load="208d" size="350" color="white" frame="true" align="right" spinBox="true" caption="208d, resolution 2.050Å" /> '''HIGH-RESOLUTION STR...
 
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,328,572 edits
No edit summary
 
(14 intermediate revisions by the same user not shown)
Line 1: Line 1:
[[Image:208d.gif|left|200px]]<br /><applet load="208d" size="350" color="white" frame="true" align="right" spinBox="true"
caption="208d, resolution 2.050&Aring;" />
'''HIGH-RESOLUTION STRUCTURE OF A DNA HELIX FORMING (C.G)*G BASE TRIPLETS'''<br />


==Overview==
==HIGH-RESOLUTION STRUCTURE OF A DNA HELIX FORMING (C.G)*G BASE TRIPLETS==
Triple helices result from interaction between single- and double-stranded, nucleic acids. Their formation is a possible mechanism for recombination, of homologous gene sequences in nature and provides, inter alia, a basis, for artificial control of gene activity. Triple-helix motifs have been, extensively studied by a variety of techniques, but few high-resolution, structural data are available. The only triplet structures characterized, so far by X-ray diffraction were in protein-DNA complexes studied at about, 3 A resolution. We report here the X-ray analysis of a DNA nonamer, d(GCGAATTCG), to a resolution of 2.05 A, in which the extended crystal, structure contains (C.G)*G triplets as a fragment of triple helix. The, guanosine-containing chains are in a parallel orientation. This, arrangement is a necessary feature of models for homologous recombination, which results ultimately in replacement of one length of DNA by another of, similar sequence. The present-structure agrees with many published, predictions of triplex organization, and provides an accurate, representation of an element that allows sequence-specific association, between single- and double-stranded nucleic acids.
<StructureSection load='208d' size='340' side='right'caption='[[208d]], [[Resolution|resolution]] 2.05&Aring;' scene=''>
 
== Structural highlights ==
==About this Structure==
<table><tr><td colspan='2'>[[208d]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=208D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=208D FirstGlance]. <br>
208D is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/ ] with <scene name='pdbligand=MG:'>MG</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=208D OCA].  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.05&#8491;</td></tr>
 
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
==Reference==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=208d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=208d OCA], [https://pdbe.org/208d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=208d RCSB], [https://www.ebi.ac.uk/pdbsum/208d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=208d ProSAT]</span></td></tr>
High-resolution structure of a DNA helix forming (C.G)*G base triplets., Van Meervelt L, Vlieghe D, Dautant A, Gallois B, Precigoux G, Kennard O, Nature. 1995 Apr 20;374(6524):742-4. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=7715732 7715732]
</table>
[[Category: Protein complex]]
__TOC__
[[Category: Dautant, A.]]
</StructureSection>
[[Category: Gallois, B.]]
[[Category: Large Structures]]
[[Category: Kennard, O.]]
[[Category: Dautant A]]
[[Category: Meervelt, L.Van.]]
[[Category: Gallois B]]
[[Category: Precigoux, G.]]
[[Category: Kennard O]]
[[Category: Vlieghe, D.]]
[[Category: Precigoux G]]
[[Category: MG]]
[[Category: Van Meervelt L]]
[[Category: b-dna]]
[[Category: Vlieghe D]]
[[Category: base triplet]]
[[Category: double helix]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jan 29 17:47:05 2008''
Retrieved from "https://proteopedia.org/208d"