216d: Difference between revisions

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New page: left|200px<br /><applet load="216d" size="350" color="white" frame="true" align="right" spinBox="true" caption="216d, resolution 1.730Å" /> '''CRYSTAL STRUCTURES ...
 
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[[Image:216d.jpg|left|200px]]<br /><applet load="216d" size="350" color="white" frame="true" align="right" spinBox="true"
caption="216d, resolution 1.730&Aring;" />
'''CRYSTAL STRUCTURES OF THE B-FORM DNA-RNA CHIMER (5'-D(*IP*)-R(*CP*)-D(*IP*CP*IP*CP*IP*C)-3') COMPLEXED WITH DISTAMYCIN'''<br />


==Overview==
==CRYSTAL STRUCTURES OF THE B-FORM DNA-RNA CHIMER (5'-D(*IP*)-R(*CP*)-D(*IP*CP*IP*CP*IP*C)-3') COMPLEXED WITH DISTAMYCIN==
Two DNA-RNA chimers, complexed with DNA minor groove binding drugs, have, been observed to adopt the B-form conformation for the first time. Thus, the RNA duplex may assume the B-DNA conformation when interacting with, drugs, peptides or proteins.
<StructureSection load='216d' size='340' side='right'caption='[[216d]], [[Resolution|resolution]] 1.73&Aring;' scene=''>
 
== Structural highlights ==
==About this Structure==
<table><tr><td colspan='2'>[[216d]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=216D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=216D FirstGlance]. <br>
216D is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/ ] with <scene name='pdbligand=DMY:'>DMY</scene> and <scene name='pdbligand=MG:'>MG</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=216D OCA].
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.73&#8491;</td></tr>
 
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DMY:DISTAMYCIN+A'>DMY</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
==Reference==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=216d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=216d OCA], [https://pdbe.org/216d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=216d RCSB], [https://www.ebi.ac.uk/pdbsum/216d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=216d ProSAT]</span></td></tr>
Crystal structures of B-form DNA-RNA chimers complexed with distamycin., Chen X, Ramakrishnan B, Sundaralingam M, Nat Struct Biol. 1995 Sep;2(9):733-5. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=7552741 7552741]
</table>
[[Category: Protein complex]]
__TOC__
[[Category: Chen, X.]]
</StructureSection>
[[Category: Ramakrishnan, B.]]
[[Category: Large Structures]]
[[Category: Sundaralingam, M.]]
[[Category: Chen X]]
[[Category: DMY]]
[[Category: Ramakrishnan B]]
[[Category: MG]]
[[Category: Sundaralingam M]]
[[Category: b-dna/rna]]
[[Category: complexed with drug]]
[[Category: double helix]]
[[Category: modified]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jan 29 17:47:28 2008''

Latest revision as of 09:08, 14 February 2024

CRYSTAL STRUCTURES OF THE B-FORM DNA-RNA CHIMER (5'-D(*IP*)-R(*CP*)-D(*IP*CP*IP*CP*IP*C)-3') COMPLEXED WITH DISTAMYCIN

216d, resolution 1.73Å

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