3rnq: Difference between revisions
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New page: '''Unreleased structure''' The entry 3rnq is ON HOLD Authors: Lazar-Molnar, E., Ramagopal, U.A., Nathenson, S.G., Almo, S.C. Description: Crystal structure of the complex between the e... |
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==Crystal structure of the complex between the extracellular domains of mouse PD-1 mutant and PD-L2== | |||
<StructureSection load='3rnq' size='340' side='right'caption='[[3rnq]], [[Resolution|resolution]] 1.60Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[3rnq]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RNQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3RNQ FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6Å</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3rnq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rnq OCA], [https://pdbe.org/3rnq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3rnq RCSB], [https://www.ebi.ac.uk/pdbsum/3rnq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3rnq ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/PD1L2_MOUSE PD1L2_MOUSE] Involved in the costimulatory signal essential for T-cell proliferation and IFNG production in a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation by blocking cell cycle progression and cytokine production.<ref>PMID:11283156</ref> <ref>PMID:11224527</ref> <ref>PMID:12719480</ref> | |||
==See Also== | |||
*[[Cell death protein 3D structures|Cell death protein 3D structures]] | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Mus musculus]] | |||
[[Category: Almo SC]] | |||
[[Category: Lazar-Molnar E]] | |||
[[Category: Nathenson SG]] | |||
[[Category: Ramagopal UA]] | |||
Latest revision as of 12:31, 14 March 2024
Crystal structure of the complex between the extracellular domains of mouse PD-1 mutant and PD-L2
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