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[[Image:3nx5.jpg|left|200px]]


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==The crystal structure of Sanguinarine bound to DNA d(CGTACG)==
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<StructureSection load='3nx5' size='340' side='right'caption='[[3nx5]], [[Resolution|resolution]] 2.31&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[3nx5]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NX5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3NX5 FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.31&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=SAU:13-METHYL[1,3]BENZODIOXOLO[5,6-C][1,3]DIOXOLO[4,5-I]PHENANTHRIDIN-13-IUM'>SAU</scene></td></tr>
{{STRUCTURE_3nx5|  PDB=3nx5  |  SCENE= }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3nx5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3nx5 OCA], [https://pdbe.org/3nx5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3nx5 RCSB], [https://www.ebi.ac.uk/pdbsum/3nx5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3nx5 ProSAT]</span></td></tr>
</table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The first crystal structures of Berberine and Sanguinarine intercalated with a d(CGTACG)(2) DNA sequence were obtained by X-ray diffraction analysis at 2.3 A resolution. Both drugs join the end of two "two-molecules" DNA units, stacked in a non-classic intercalation site formed by six bases. Sanguinarine interacts with d(CGTACG)(2) DNA in its iminium form.


===The crystal structure of Sanguinarine bound to DNA d(CGTACG)===
X-Ray diffraction analyses of the natural isoquinoline alkaloids Berberine and Sanguinarine complexed with double helix DNA d(CGTACG).,Ferraroni M, Bazzicalupi C, Bilia AR, Gratteri P Chem Commun (Camb). 2011 May 7;47(17):4917-9. Epub 2011 Mar 22. PMID:21431128<ref>PMID:21431128</ref>


 
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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The line below this paragraph, {{ABSTRACT_PUBMED_21431128}}, adds the Publication Abstract to the page
<div class="pdbe-citations 3nx5" style="background-color:#fffaf0;"></div>
(as it appears on PubMed at http://www.pubmed.gov), where 21431128 is the PubMed ID number.
== References ==
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<references/>
{{ABSTRACT_PUBMED_21431128}}
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</StructureSection>
==About this Structure==
[[Category: Large Structures]]
[[3nx5]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NX5 OCA].
[[Category: Bazzicalupi C]]
 
[[Category: Bilia AR]]
==Reference==
[[Category: Ferraroni M]]
<ref group="xtra">PMID:021431128</ref><references group="xtra"/>
[[Category: Gratteri P]]
[[Category: Bazzicalupi, C.]]
[[Category: Bilia, A R.]]
[[Category: Ferraroni, M.]]
[[Category: Gratteri, P.]]
Retrieved from "https://proteopedia.org/3nx5"