284d: Difference between revisions

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New page: left|200px<br /><applet load="284d" size="350" color="white" frame="true" align="right" spinBox="true" caption="284d, resolution 1.100Å" /> '''THE BI-LOOP, A NEW ...
 
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[[Image:284d.gif|left|200px]]<br /><applet load="284d" size="350" color="white" frame="true" align="right" spinBox="true"
caption="284d, resolution 1.100&Aring;" />
'''THE BI-LOOP, A NEW GENERAL FOUR-STRANDED DNA MOTIF'''<br />


==Overview==
==THE BI-LOOP, A NEW GENERAL FOUR-STRANDED DNA MOTIF==
The crystal structure of the cyclic octanucleotide d&lt;pATTCATTC&gt; contains, two independent molecules that form a novel quadruplex by means of, intermolecular Watson-Crick A.T pairs and base stacking. A virtually, identical quadruplex composed of G.C pairs was found by earlier x-ray, analysis of the linear heptamer d(GCATGCT), when the DNA was looped in the, crystal. The close correspondence between these two structures of markedly, dissimilar oligonucleotides suggests that they are both examples of a, previously unrecognized motif. Their nucleotide sequences have little in, common except for two separated 5'-purine-pyrimidine dinucleotides forming, the quadruplex, and by implication these so-called "bi-loops" could occur, widely in natural DNA. Such structures provide a mechanism for noncovalent, linking of polynucleotides in vivo. Their capacity to associate by base, stacking, demonstrated in the crystal structure of d(GCATGCT), creates a, compact molecular framework made up of four DNA chains within which strand, exchange could take place.
<StructureSection load='284d' size='340' side='right'caption='[[284d]], [[Resolution|resolution]] 1.10&Aring;' scene=''>
 
== Structural highlights ==
==About this Structure==
<table><tr><td colspan='2'>[[284d]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=284D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=284D FirstGlance]. <br>
284D is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/ ] with <scene name='pdbligand=NA:'>NA</scene> and <scene name='pdbligand=BA:'>BA</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=284D OCA].  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.1&#8491;</td></tr>
 
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BA:BARIUM+ION'>BA</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
==Reference==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=284d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=284d OCA], [https://pdbe.org/284d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=284d RCSB], [https://www.ebi.ac.uk/pdbsum/284d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=284d ProSAT]</span></td></tr>
The bi-loop, a new general four-stranded DNA motif., Salisbury SA, Wilson SE, Powell HR, Kennard O, Lubini P, Sheldrick GM, Escaja N, Alazzouzi E, Grandas A, Pedroso E, Proc Natl Acad Sci U S A. 1997 May 27;94(11):5515-8. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=9159103 9159103]
</table>
[[Category: Protein complex]]
__TOC__
[[Category: Alazzouzi, E.]]
</StructureSection>
[[Category: Escaja, N.]]
[[Category: Large Structures]]
[[Category: Grandas, A.]]
[[Category: Alazzouzi E]]
[[Category: Kennard, O.]]
[[Category: Escaja N]]
[[Category: Lubini, P.]]
[[Category: Grandas A]]
[[Category: Pedroso, E.]]
[[Category: Kennard O]]
[[Category: Powell, H.R.]]
[[Category: Lubini P]]
[[Category: Salisbury, S.A.]]
[[Category: Pedroso E]]
[[Category: Sheldrick, G.M.]]
[[Category: Powell HR]]
[[Category: Wilson, S.E.]]
[[Category: Salisbury SA]]
[[Category: BA]]
[[Category: Sheldrick GM]]
[[Category: NA]]
[[Category: Wilson SE]]
[[Category: bi-loop]]
[[Category: cyclic b-dna]]
[[Category: quadruple helix]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jan 29 17:50:38 2008''

Latest revision as of 09:10, 14 February 2024

THE BI-LOOP, A NEW GENERAL FOUR-STRANDED DNA MOTIF

284d, resolution 1.10Å

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