294d: Difference between revisions

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New page: left|200px<br /><applet load="294d" size="350" color="white" frame="true" align="right" spinBox="true" caption="294d, resolution 2.500Å" /> '''INTERCALATED CYTOSI...
 
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[[Image:294d.gif|left|200px]]<br /><applet load="294d" size="350" color="white" frame="true" align="right" spinBox="true"
caption="294d, resolution 2.500&Aring;" />
'''INTERCALATED CYTOSINE MOTIF AND NOVEL ADENINE CLUSTERS IN THE CRYSTAL STRUCTURE OF TETRAHYMENA TELOMERE'''<br />


==Overview==
==INTERCALATED CYTOSINE MOTIF AND NOVEL ADENINE CLUSTERS IN THE CRYSTAL STRUCTURE OF TETRAHYMENA TELOMERE==
The cytosine-rich strand of the Tetrahymena telomere consists of multiple, repeats of sequence d(AACCCC). We have solved the crystal structure of the, crystalline repeat sequence at 2.5 A resolution. The adenines form two, different and previously unknown clusters (A clusters) in orthogonal, directions with their counterparts from other strands, each containing a, total of eight adenines. The clusters appear to be stable aggregates held, together by base stacking and three different base-pairing modes. Two, different types of cytosine tetraplexes are found in the crystal. Each, four-stranded complex is composed of two intercalated parallel-stranded, duplexes pointing in opposite directions, with hemiprotonated, cytosine-cytosine (C.C+) base pairs. The outermost C.C+base pairs are from, the 5'-end of each strand in one cytosine tetraplex and from the 3'-end of, each strand in the other. The A clusters and the cytosine tetraplexes form, two alternating stacking patterns, creating continuous base stacking in, two perpendicular directions along the x - and z -axes. The adenine, clusters could be organizational motifs for macromolecular RNA.
<StructureSection load='294d' size='340' side='right'caption='[[294d]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
 
== Structural highlights ==
==About this Structure==
<table><tr><td colspan='2'>[[294d]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=294D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=294D FirstGlance]. <br>
294D is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=294D OCA].  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
 
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=294d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=294d OCA], [https://pdbe.org/294d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=294d RCSB], [https://www.ebi.ac.uk/pdbsum/294d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=294d ProSAT]</span></td></tr>
==Reference==
</table>
Intercalated cytosine motif and novel adenine clusters in the crystal structure of the Tetrahymena telomere., Cai L, Chen L, Raghavan S, Ratliff R, Moyzis R, Rich A, Nucleic Acids Res. 1998 Oct 15;26(20):4696-705. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=9753739 9753739]
__TOC__
[[Category: Protein complex]]
</StructureSection>
[[Category: Cai, L.]]
[[Category: Large Structures]]
[[Category: Chen, L.]]
[[Category: Cai L]]
[[Category: Moyzis, R.]]
[[Category: Chen L]]
[[Category: Raghavan, S.]]
[[Category: Moyzis R]]
[[Category: Ratliff, R.]]
[[Category: Raghavan S]]
[[Category: Rich, A.]]
[[Category: Ratliff R]]
[[Category: adenine-cluster]]
[[Category: Rich A]]
[[Category: base intercalated]]
[[Category: continuous base stacking]]
[[Category: flipped-out bases]]
[[Category: parallel-stranded tetraplex]]
[[Category: quadruple helix]]
[[Category: unusual dna]]
 
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Latest revision as of 09:10, 14 February 2024

INTERCALATED CYTOSINE MOTIF AND NOVEL ADENINE CLUSTERS IN THE CRYSTAL STRUCTURE OF TETRAHYMENA TELOMERE

294d, resolution 2.50Å

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