Thiolase: Difference between revisions

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~~[[Image:2iik.png|left|200px|thumb|Crystal Structure of Thiolase, [[2iik]]]]~~

~~{{STRUCTURE_2iik| PDB~~=~~2iik | SIZE~~=~~300| SCENE~~=~~Thiolase/Thiolase/1 |~~right~~|CAPTION~~=Human 3-ketoacyl-CoA ~~thiolase,~~ [[~~2iik~~]] }}

== Function ==

Two different classes of '''thiolases''' are found.<br />

'''~~Thiolase~~''' ~~involves two different thiolases~~ . ~~The~~ 3-ketoacyl-CoA thiolase (KCT) is involved in fatty acid β oxidation. ~~Acetoacetyl~~-CoA thiolase (ACT) is involved in the thiolysis of acetoacetyl-CoA.

*'''Degrative thiolase''' like '''3-ketoacyl-CoA thiolase''' (KCT) is involved in fatty acid [[beta oxidation]]<ref>PMID:16630629</ref>.<br />

~~{{TOC limit|limit=2}}~~

*'''Biosynthetic thiolases''' like '''acetoacetyl-CoA thiolase''' (ACT) or '''acetyl-CoA acetyltransferase''' are involved in the thiolysis of acetoacetyl-CoA<ref>PMID:21908473</ref>.

~~== 3D Structures of Thiolase ==~~

For bacterial thiolase see [[Bacterial thiolase]]

*'''SCP2-thiolase''' converts in the bile acid synthesis pathway 24-keto-THC-CoA into choloyl-CoA and propionyl-CoA<ref>PMID:30573650</ref>. For zebrafish thiolase see [[SCP2-thiolase]]. ''' SCP''' is Sterol Carrier Protein.

*'''U34-tRNA-thiolase''' thiolates uridine 34 in tRNA anticodon loop which guarantees the fidelity of protein translation in archaea<ref>PMID:37005440</ref>.

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-[[Image:2iik.png|left|200px|thumb|Crystal Structure of Thiolase, [[2iik]]]]
+<StructureSection load='4c2j' size='350' side='right' caption='Human 3-ketoacyl-CoA complex with CoA and ethylene glycol (PDB code [[4c2j]])' scene='44/447919/Cv/7'>
-{{STRUCTURE_2iik|  PDB=2iik  | SIZE=300| SCENE=Thiolase/Thiolase/1 |right|CAPTION=Human 3-ketoacyl-CoA thiolase, [[2iik]] }}
+== Function ==
+Two different classes of '''thiolases''' are found.<br />
-'''Thiolase''' involves two different thiolases .  The 3-ketoacyl-CoA thiolase (KCT) is involved in fatty acid β oxidation. Acetoacetyl-CoA thiolase (ACT) is involved in the thiolysis of acetoacetyl-CoA.
+*'''Degrative thiolase''' like '''3-ketoacyl-CoA thiolase''' (KCT) is involved in fatty acid [[beta oxidation]]<ref>PMID:16630629</ref>.<br />
-{{TOC limit|limit=2}}
+*'''Biosynthetic thiolases''' like '''acetoacetyl-CoA thiolase''' (ACT) or '''acetyl-CoA acetyltransferase''' are involved in the thiolysis of acetoacetyl-CoA<ref>PMID:21908473</ref>.
-== 3D Structures of Thiolase ==
+For bacterial thiolase see [[Bacterial thiolase]]
+*'''SCP2-thiolase''' converts in the bile acid synthesis pathway 24-keto-THC-CoA into choloyl-CoA and propionyl-CoA<ref>PMID:30573650</ref>.  For zebrafish thiolase see [[SCP2-thiolase]]. ''' SCP''' is Sterol Carrier Protein.
+*'''U34-tRNA-thiolase''' thiolates uridine 34 in tRNA anticodon loop which guarantees the fidelity of protein translation in archaea<ref>PMID:37005440</ref>.
+See also [[Mevalonate pathway]]
+== Structural highlights ==
+The <scene name='44/447919/Cv/8'>active site of 3-ketoacyl-CoA thiolase contains CoA</scene><ref>PMID:25478839</ref>. Water molecules are shown as red spheres.
+== 3D Structures of Thiolase ==
+[[Thiolase 3D structures]]
+</StructureSection>
+== References ==
+<references/>
 [[Category:Topic Page]]