3chn: Difference between revisions

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[[Image:3chn.png|left|200px]]


<!--
==Solution structure of human secretory IgA1==
The line below this paragraph, containing "STRUCTURE_3chn", creates the "Structure Box" on the page.
<StructureSection load='3chn' size='340' side='right'caption='[[3chn]]' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[3chn]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CHN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3CHN FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray solution scattering</td></tr>
-->
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3chn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3chn OCA], [https://pdbe.org/3chn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3chn RCSB], [https://www.ebi.ac.uk/pdbsum/3chn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3chn ProSAT]</span></td></tr>
{{STRUCTURE_3chn|  PDB=3chn  |  SCENE=  }}
</table>
 
== Disease ==
===Solution structure of human secretory IgA1===
[https://www.uniprot.org/uniprot/IGHA1_HUMAN IGHA1_HUMAN] Note=A chromosomal aberration involving IGHA1 is found in multiple myeloma (MM) cell lines. Translocation t(1;14)(q21;q32) that forms a FCRL4-IGHA1 fusion protein.
 
== Function ==
 
[https://www.uniprot.org/uniprot/IGHA1_HUMAN IGHA1_HUMAN] Ig alpha is the major immunoglobulin class in body secretions. It may serve both to defend against local infection and to prevent access of foreign antigens to the general immunologic system.
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== Evolutionary Conservation ==
The line below this paragraph, {{ABSTRACT_PUBMED_19079336}}, adds the Publication Abstract to the page
[[Image:Consurf_key_small.gif|200px|right]]
(as it appears on PubMed at http://www.pubmed.gov), where 19079336 is the PubMed ID number.
Check<jmol>
-->
  <jmolCheckbox>
{{ABSTRACT_PUBMED_19079336}}
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ch/3chn_consurf.spt"</scriptWhenChecked>
 
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
==About this Structure==
    <text>to colour the structure by Evolutionary Conservation</text>
[[3chn]] is a 10 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CHN OCA].  
  </jmolCheckbox>
 
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3chn ConSurf].
==See Also==
<div style="clear:both"></div>
*[[IgA]]
__TOC__
 
</StructureSection>
==Reference==
<ref group="xtra">PMID:019079336</ref><references group="xtra"/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Almogren, A.]]
[[Category: Large Structures]]
[[Category: Bonner, A.]]
[[Category: Almogren A]]
[[Category: Furtado, P B.]]
[[Category: Bonner A]]
[[Category: Kerr, M A.]]
[[Category: Furtado PB]]
[[Category: Perkins, S J.]]
[[Category: Kerr MA]]
[[Category: Perkins SJ]]
Retrieved from "https://proteopedia.org/3chn"