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'''Unreleased structure'''


The entry 3ru0 is ON HOLD
==Cocrystal structure of human SMYD3 with inhibitor Sinefungin bound==
 
<StructureSection load='3ru0' size='340' side='right'caption='[[3ru0]], [[Resolution|resolution]] 1.85&Aring;' scene=''>
Authors: Foreman, K.W., Brown, M., Park, F., Emtage, S., Harriss, J., Das, C., Zhu, L., Crew, A., Arnold, L., Shaaban, S., Tucker, P.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[3ru0]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RU0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3RU0 FirstGlance]. <br>
Description: Cocrystal structure of human SMYD3 with inhibitor Sinefungin bound
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.849&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SFG:SINEFUNGIN'>SFG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ru0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ru0 OCA], [https://pdbe.org/3ru0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ru0 RCSB], [https://www.ebi.ac.uk/pdbsum/3ru0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ru0 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/SMYD3_HUMAN SMYD3_HUMAN] Histone methyltransferase. Specifically methylates 'Lys-4' and 'Lys-5' of histone H3, inducing di- and tri-methylation, but not monomethylation. Plays an important role in transcriptional activation as a member of an RNA polymerase complex. Binds DNA containing 5'-CCCTCC-3' or 5'-GAGGGG-3' sequences.<ref>PMID:15235609</ref> <ref>PMID:22419068</ref>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Arnold L]]
[[Category: Brown M]]
[[Category: Crew A]]
[[Category: Das C]]
[[Category: Emtage S]]
[[Category: Foreman KW]]
[[Category: Harriss J]]
[[Category: Park F]]
[[Category: Shaaban S]]
[[Category: Tucker P]]
[[Category: Zhu L]]
Retrieved from "https://proteopedia.org/3ru0"