3rwr: Difference between revisions

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New page: '''Unreleased structure''' The entry 3rwr is ON HOLD Authors: Andres, S.N, Junop, M.S. Description: Crystal structure of the human XRCC4-XLF complex
 
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'''Unreleased structure'''


The entry 3rwr is ON HOLD
==Crystal structure of the human XRCC4-XLF complex==
 
<StructureSection load='3rwr' size='340' side='right'caption='[[3rwr]], [[Resolution|resolution]] 3.94&Aring;' scene=''>
Authors: Andres, S.N, Junop, M.S.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[3rwr]] is a 24 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RWR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3RWR FirstGlance]. <br>
Description: Crystal structure of the human XRCC4-XLF complex
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.943&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3rwr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rwr OCA], [https://pdbe.org/3rwr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3rwr RCSB], [https://www.ebi.ac.uk/pdbsum/3rwr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3rwr ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/XRCC4_HUMAN XRCC4_HUMAN] Involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination. Binds to DNA and to DNA ligase IV (LIG4). The LIG4-XRCC4 complex is responsible for the NHEJ ligation step, and XRCC4 enhances the joining activity of LIG4. Binding of the LIG4-XRCC4 complex to DNA ends is dependent on the assembly of the DNA-dependent protein kinase complex DNA-PK to these DNA ends.<ref>PMID:8548796</ref> <ref>PMID:10854421</ref> <ref>PMID:10757784</ref> <ref>PMID:16412978</ref>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Andres SN]]
[[Category: Junop MS]]
Retrieved from "https://proteopedia.org/3rwr"