Chitinase: Difference between revisions

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~~[[Image:1ffq.png|left|200px|thumb|Crystal Structure of Chitinase I from~~ ''~~Serratia marcescens~~'' complex with ~~inhibitor,~~ [[~~1ffq]]~~]]

~~{{STRUCTURE_1ffq| PDB~~=~~1ffq | SIZE~~=~~300| SCENE~~=~~Chitinases/Cv/1 |right|CAPTION~~=~~Chitinase I from ''Serratia marcescens'' complex with inhibitor, [[1ffq]] }}~~

__TOC__

== Function ==

[[Chitinase]]s (Chi) cleave the beta-1-4-glycosidic bond between the N-acetyl-D-glucosamine units of which chitin is comprised. Chitinases are present in plants, bacteria and fungi. The first chitinase structures were solved in 1994, from a bacterium ([[1ctn]]) and a plant ([[2hvm]]). A mechanism for chitin cleavage was proposed based on several structures and was later confirmed. <ref>PMID:21054166</ref>.

* '''Chitinase I''' is found in plants.

* '''Chitinase II''' is found in plants, fungi and bacteria.

* '''Chitinase III''' has no sequence similarity to class I or II.

* '''Chitinase IV''' has similar characteristics to class I but are smaller than it.

~~[[Chitinases]] cleave the beta-1-4-glycosidic bond between the N-acetyl-D-glucosamine units~~ of ~~which chitin is comprised~~. ~~Chitinases~~ are ~~present in plants, bacteria and fungi~~. ~~The first chitinase structures were solved in 1994, from a bacterium (~~[[~~1ctn~~]]~~) and a plant (~~[[~~2hvm~~]]~~). A mechanism for chitin cleavage was proposed based on several structures and was later confirmed.~~

==Disease ==

Chi is related to allergies and asthma<ref>PMID:19295241</ref>.

== Structural highlights ==

The <scene name='27/271631/Cv/5'>chitin tetrasaccharide binding site</scene> of Chitinase A. <ref>PMID:24582745</ref> Water molecules are shown as red spheres.

== 3D Structures of Chitinase ==

[[Chitinase 3D structures]]

</StructureSection>

== References ==

[[Category:Topic Page]]

Chitinase: Difference between revisions

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-[[Image:1ffq.png|left|200px|thumb|Crystal Structure of Chitinase I from ''Serratia marcescens'' complex with inhibitor, [[1ffq]]]]
+<StructureSection load='3wh1' size='350' side='right' caption='Chitinase A complex with (GlcNac)4 and ethylene glycol (PDB entry [[3wh1]])' scene='27/271631/Cv/3'>
-{{STRUCTURE_1ffq|  PDB=1ffq  | SIZE=300| SCENE=Chitinases/Cv/1 |right|CAPTION=Chitinase I from ''Serratia marcescens'' complex with inhibitor, [[1ffq]] }}
+__TOC__
+== Function ==
+[[Chitinase]]s (Chi) cleave the beta-1-4-glycosidic bond between the N-acetyl-D-glucosamine units of which chitin is comprised. Chitinases are present in plants, bacteria and fungi. The first chitinase structures were solved in 1994, from a bacterium ([[1ctn]]) and a plant ([[2hvm]]). A mechanism for chitin cleavage was proposed based on several structures and was later confirmed. <ref>PMID:21054166</ref>. <br />
+* '''Chitinase I''' is found in plants.<br />
+* '''Chitinase II''' is found in plants, fungi and bacteria.<br />
+* '''Chitinase III''' has no sequence similarity to class I or II.<br />
+* '''Chitinase IV''' has similar characteristics to class I but are smaller than it.<br />
-[[Chitinases]] cleave the beta-1-4-glycosidic bond between the N-acetyl-D-glucosamine units of which chitin is comprised. Chitinases are present in plants, bacteria and fungi. The first chitinase structures were solved in 1994, from a bacterium ([[1ctn]]) and a plant ([[2hvm]]). A mechanism for chitin cleavage was proposed based on several structures and was later confirmed.
+==Disease ==
+Chi is related to allergies and asthma<ref>PMID:19295241</ref>.
+== Structural highlights ==
+The <scene name='27/271631/Cv/5'>chitin tetrasaccharide binding site</scene> of Chitinase A. <ref>PMID:24582745</ref> Water molecules are shown as red spheres.
+== 3D Structures of Chitinase ==
+[[Chitinase 3D structures]]
+</StructureSection>
+== References ==
+<references/>
+[[Category:Topic Page]]