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New page: left|200px<br /><applet load="2bm7" size="350" color="white" frame="true" align="right" spinBox="true" caption="2bm7, resolution 2.7Å" /> '''THE STRUCTURE OF MFPA...
 
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[[Image:2bm7.gif|left|200px]]<br /><applet load="2bm7" size="350" color="white" frame="true" align="right" spinBox="true"
caption="2bm7, resolution 2.7&Aring;" />
'''THE STRUCTURE OF MFPA (RV3361C, P3221 CRYSTAL FORM). THE PENTAPEPTIDE REPEAT PROTEIN FROM MYCOBACTERIUM TUBERCULOSIS FOLDS AS A RIGHT-HANDED QUADRILATERAL BETA-HELIX.'''<br />


==Overview==
==The Structure of MfpA (Rv3361c, P3221 Crystal form). The Pentapeptide Repeat Protein from Mycobacterium tuberculosis Folds as A Right- handed Quadrilateral Beta-helix.==
Fluoroquinolones are gaining increasing importance in the treatment of, tuberculosis. The expression of MfpA, a member of the pentapeptide repeat, family of proteins from Mycobacterium tuberculosis, causes resistance to, ciprofloxacin and sparfloxacin. This protein binds to DNA gyrase and, inhibits its activity. Its three-dimensional structure reveals a fold, which we have named the right-handed quadrilateral beta helix, that, exhibits size, shape, and electrostatic similarity to B-form DNA. This, represents a form of DNA mimicry and explains both its inhibitory effect, on DNA gyrase and fluoroquinolone resistance resulting from the protein's, expression in vivo.
<StructureSection load='2bm7' size='340' side='right'caption='[[2bm7]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
 
== Structural highlights ==
==About this Structure==
<table><tr><td colspan='2'>[[2bm7]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BM7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2BM7 FirstGlance]. <br>
2BM7 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BM7 OCA].  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
 
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2bm7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bm7 OCA], [https://pdbe.org/2bm7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2bm7 RCSB], [https://www.ebi.ac.uk/pdbsum/2bm7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2bm7 ProSAT]</span></td></tr>
==Reference==
</table>
A fluoroquinolone resistance protein from Mycobacterium tuberculosis that mimics DNA., Hegde SS, Vetting MW, Roderick SL, Mitchenall LA, Maxwell A, Takiff HE, Blanchard JS, Science. 2005 Jun 3;308(5727):1480-3. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15933203 15933203]
== Function ==
[[Category: Mycobacterium tuberculosis]]
[https://www.uniprot.org/uniprot/O50390_MYCTO O50390_MYCTO]  
[[Category: Single protein]]
== Evolutionary Conservation ==
[[Category: Blanchard, J.S.]]
[[Image:Consurf_key_small.gif|200px|right]]
[[Category: Hegde, S.S.]]
Check<jmol>
[[Category: Maxwell, A.]]
  <jmolCheckbox>
[[Category: Mitchenall, L.A.]]
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bm/2bm7_consurf.spt"</scriptWhenChecked>
[[Category: Roderick, S.L.]]
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
[[Category: Takiff, H.E.]]
    <text>to colour the structure by Evolutionary Conservation</text>
[[Category: Vetting, M.W.]]
  </jmolCheckbox>
[[Category: dna gyrase]]
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2bm7 ConSurf].
[[Category: dna mimicry]]
<div style="clear:both"></div>
[[Category: fluroquinolone resistance]]
__TOC__
[[Category: pentapeptide repeat protein]]
</StructureSection>
[[Category: right-handed quadrilateral beta-helix]]
[[Category: Large Structures]]
 
[[Category: Mycobacterium tuberculosis H37Rv]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jan 29 18:26:59 2008''
[[Category: Blanchard JS]]
[[Category: Hegde SS]]
[[Category: Maxwell A]]
[[Category: Mitchenall LA]]
[[Category: Roderick SL]]
[[Category: Takiff HE]]
[[Category: Vetting MW]]

Latest revision as of 06:38, 1 May 2024

The Structure of MfpA (Rv3361c, P3221 Crystal form). The Pentapeptide Repeat Protein from Mycobacterium tuberculosis Folds as A Right- handed Quadrilateral Beta-helix.

2bm7, resolution 2.70Å

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