2ld8: Difference between revisions
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New page: '''Unreleased structure''' The entry 2ld8 is ON HOLD Authors: Heddi, B., Phan, A. Description: Structure of Human Telomeric DNA in Crowded Solution |
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==Structure of Human Telomeric DNA in Crowded Solution== | |||
<StructureSection load='2ld8' size='340' side='right'caption='[[2ld8]]' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[2ld8]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LD8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LD8 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ld8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ld8 OCA], [https://pdbe.org/2ld8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ld8 RCSB], [https://www.ebi.ac.uk/pdbsum/2ld8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ld8 ProSAT]</span></td></tr> | |||
</table> | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
G-quadruplex structures formed by DNA at the human telomeres are attractive anticancer targets. Human telomeric sequences can adopt a diverse range of intramolecular G-quadruplex conformations: a parallel-stranded conformation was observed in the crystalline state, while at least four other forms were seen in K(+) solution, raising the question of which conformation is favored in crowded cellular environment. Here, we report the first NMR structure of a human telomeric G-quadruplex in crowded solution. We show that four different G-quadruplex conformations are converted to a propeller-type parallel-stranded G-quadruplex in K(+)-containing crowded solution due to water depletion. This study also reveals the formation of a new higher-order G-quadruplex structure under molecular crowding conditions. Our molecular dynamics simulations of solvent distribution provide insights at molecular level on the formation of parallel-stranded G-quadruplex in environment depleted of water. These results regarding human telomeric DNA can be extended to oncogenic promoters and other genomic G-rich sequences. | |||
Structure of Human Telomeric DNA in Crowded Solution.,Heddi B, Phan AT J Am Chem Soc. 2011 Jun 29;133(25):9824-9833. Epub 2011 Jun 6. PMID:21548653<ref>PMID:21548653</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
</div> | |||
<div class="pdbe-citations 2ld8" style="background-color:#fffaf0;"></div> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Heddi B]] | |||
[[Category: Phan AT]] | |||
Latest revision as of 05:41, 15 May 2024
Structure of Human Telomeric DNA in Crowded Solution
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