2ld8: Difference between revisions

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~~'''Unreleased structure'''~~

~~The entry~~ 2ld8 is ~~ON HOLD~~

==Structure of Human Telomeric DNA in Crowded Solution==

== Structural highlights ==

<table><tr><td colspan='2'>[[2ld8]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LD8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LD8 FirstGlance]. <br>

</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ld8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ld8 OCA], [https://pdbe.org/2ld8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ld8 RCSB], [https://www.ebi.ac.uk/pdbsum/2ld8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ld8 ProSAT]</span></td></tr>

</table>

== Publication Abstract from PubMed ==

G-quadruplex structures formed by DNA at the human telomeres are attractive anticancer targets. Human telomeric sequences can adopt a diverse range of intramolecular G-quadruplex conformations: a parallel-stranded conformation was observed in the crystalline state, while at least four other forms were seen in K(+) solution, raising the question of which conformation is favored in crowded cellular environment. Here, we report the first NMR structure of a human telomeric G-quadruplex in crowded solution. We show that four different G-quadruplex conformations are converted to a propeller-type parallel-stranded G-quadruplex in K(+)-containing crowded solution due to water depletion. This study also reveals the formation of a new higher-order G-quadruplex structure under molecular crowding conditions. Our molecular dynamics simulations of solvent distribution provide insights at molecular level on the formation of parallel-stranded G-quadruplex in environment depleted of water. These results regarding human telomeric DNA can be extended to oncogenic promoters and other genomic G-rich sequences.

~~Authors:~~ Heddi, B., Phan~~, A~~.

Structure of Human Telomeric DNA in Crowded Solution.,Heddi B, Phan AT J Am Chem Soc. 2011 Jun 29;133(25):9824-9833. Epub 2011 Jun 6. PMID:21548653<ref>PMID:21548653</ref>

~~Description~~: ~~Structure of Human Telomeric DNA in Crowded Solution~~

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>

</div>

== References ==

__TOC__

</StructureSection>

[[Category: Large Structures]]

[[Category: Heddi B]]

[[Category: Phan AT]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 2ld8 is ON HOLD
+==Structure of Human Telomeric DNA in Crowded Solution==
+<StructureSection load='2ld8' size='340' side='right'caption='[[2ld8]]' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[2ld8]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LD8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LD8 FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ld8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ld8 OCA], [https://pdbe.org/2ld8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ld8 RCSB], [https://www.ebi.ac.uk/pdbsum/2ld8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ld8 ProSAT]</span></td></tr>
+</table>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+G-quadruplex structures formed by DNA at the human telomeres are attractive anticancer targets. Human telomeric sequences can adopt a diverse range of intramolecular G-quadruplex conformations: a parallel-stranded conformation was observed in the crystalline state, while at least four other forms were seen in K(+) solution, raising the question of which conformation is favored in crowded cellular environment. Here, we report the first NMR structure of a human telomeric G-quadruplex in crowded solution. We show that four different G-quadruplex conformations are converted to a propeller-type parallel-stranded G-quadruplex in K(+)-containing crowded solution due to water depletion. This study also reveals the formation of a new higher-order G-quadruplex structure under molecular crowding conditions. Our molecular dynamics simulations of solvent distribution provide insights at molecular level on the formation of parallel-stranded G-quadruplex in environment depleted of water. These results regarding human telomeric DNA can be extended to oncogenic promoters and other genomic G-rich sequences.
-Authors: Heddi, B., Phan, A.
+Structure of Human Telomeric DNA in Crowded Solution.,Heddi B, Phan AT J Am Chem Soc. 2011 Jun 29;133(25):9824-9833. Epub 2011 Jun 6. PMID:21548653<ref>PMID:21548653</ref>
-Description: Structure of Human Telomeric DNA in Crowded Solution
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+</div>
+<div class="pdbe-citations 2ld8" style="background-color:#fffaf0;"></div>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Large Structures]]
+[[Category: Heddi B]]
+[[Category: Phan AT]]