3ox3: Difference between revisions

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[[Image:3ox3.jpg|left|200px]]


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==X-ray Structural study of quinone reductase II inhibition by compounds with micromolar to nanomolar range IC50 values==
The line below this paragraph, containing "STRUCTURE_3ox3", creates the "Structure Box" on the page.
<StructureSection load='3ox3' size='340' side='right'caption='[[3ox3]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)  
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[3ox3]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OX3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3OX3 FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
-->
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=4X4:N-[2-(2-METHOXY-1H-DIPYRIDO[2,3-A 3,2-E]PYRROLIZIN-11-YL)ETHYL]FURAN-2-CARBOXAMIDE'>4X4</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
{{STRUCTURE_3ox3|  PDB=3ox3  |  SCENE= }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ox3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ox3 OCA], [https://pdbe.org/3ox3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ox3 RCSB], [https://www.ebi.ac.uk/pdbsum/3ox3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ox3 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/NQO2_HUMAN NQO2_HUMAN] The enzyme apparently serves as a quinone reductase in connection with conjugation reactions of hydroquinones involved in detoxification pathways as well as in biosynthetic processes such as the vitamin K-dependent gamma-carboxylation of glutamate residues in prothrombin synthesis.<ref>PMID:18254726</ref>


===X-ray Structural study of quinone reductase II inhibition by compounds with micromolar to nanomolar range IC50 values===
==See Also==
 
*[[Quinone reductase 3D structures|Quinone reductase 3D structures]]
 
== References ==
<!--
<references/>
The line below this paragraph, {{ABSTRACT_PUBMED_21538647}}, adds the Publication Abstract to the page
__TOC__
(as it appears on PubMed at http://www.pubmed.gov), where 21538647 is the PubMed ID number.
</StructureSection>
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{{ABSTRACT_PUBMED_21538647}}
 
==About this Structure==
[[3ox3]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OX3 OCA].
 
==Reference==
<ref group="xtra">PMID:021538647</ref><references group="xtra"/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Boutin, J A.]]
[[Category: Large Structures]]
[[Category: Delagrange, P.]]
[[Category: Boutin JA]]
[[Category: Ferry, G.]]
[[Category: Delagrange P]]
[[Category: Mesecar, A D.]]
[[Category: Ferry G]]
[[Category: Pegan, S D.]]
[[Category: Mesecar AD]]
[[Category: Sturdy, M.]]
[[Category: Pegan SD]]
[[Category: Sturdy M]]

Latest revision as of 10:37, 21 February 2024

X-ray Structural study of quinone reductase II inhibition by compounds with micromolar to nanomolar range IC50 values

3ox3, resolution 1.80Å

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