2yin: Difference between revisions

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[[Image:2yin.jpg|left|200px]]


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==STRUCTURE OF THE COMPLEX BETWEEN Dock2 AND Rac1.==
The line below this paragraph, containing "STRUCTURE_2yin", creates the "Structure Box" on the page.
<StructureSection load='2yin' size='340' side='right'caption='[[2yin]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)  
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[2yin]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YIN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2YIN FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2yin FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yin OCA], [https://pdbe.org/2yin PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2yin RCSB], [https://www.ebi.ac.uk/pdbsum/2yin PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2yin ProSAT]</span></td></tr>
{{STRUCTURE_2yin|  PDB=2yin  |  SCENE=  }}
</table>
== Function ==
[https://www.uniprot.org/uniprot/DOCK2_HUMAN DOCK2_HUMAN] Involved in cytoskeletal rearrangements required for lymphocyte migration in response of chemokines. Activates RAC1 and RAC2, but not CDC42, by functioning as a guanine nucleotide exchange factor (GEF), which exchanges bound GDP for free GTP. May also participate in IL2 transcriptional activation via the activation of RAC2.<ref>PMID:21613211</ref>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
DOCK (dedicator of cytokinesis) guanine nucleotide exchange factors (GEFs) activate the Rho-family GTPases Rac and Cdc42 to control cell migration, morphogenesis, and phagocytosis. The DOCK A and B subfamilies activate Rac, whereas the DOCK D subfamily activates Cdc42. Nucleotide exchange is catalyzed by a conserved DHR2 domain (DOCK(DHR2)). Although the molecular basis for DOCK(DHR2)-mediated GTPase activation has been elucidated through structures of a DOCK9(DHR2)-Cdc42 complex, the factors determining recognition of specific GTPases are unknown. To understand the molecular basis for DOCK-GTPase specificity, we have determined the crystal structure of DOCK2(DHR2) in complex with Rac1. DOCK2(DHR2) and DOCK9(DHR2) exhibit similar tertiary structures and homodimer interfaces and share a conserved GTPase-activating mechanism. Multiple structural differences between DOCK2(DHR2) and DOCK9(DHR2) account for their selectivity toward Rac1 and Cdc42. Key determinants of selectivity of Cdc42 and Rac for their cognate DOCK(DHR2) are a Phe or Trp residue within beta3 (residue 56) and the ability of DOCK proteins to exploit differences in the GEF-induced conformational changes of switch 1 dependent on a divergent residue at position 27. DOCK proteins, therefore, differ from DH-PH GEFs that select their cognate GTPases through recognition of structural differences within the beta2/beta3 strands.


===STRUCTURE OF THE COMPLEX BETWEEN DOCK2 AND RAC1.===
Multiple Factors Confer Specific Cdc42 and Rac Protein Activation by Dedicator of Cytokinesis (DOCK) Nucleotide Exchange Factors.,Kulkarni K, Yang J, Zhang Z, Barford D J Biol Chem. 2011 Jul 15;286(28):25341-51. Epub 2011 May 24. PMID:21613211<ref>PMID:21613211</ref>


From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 2yin" style="background-color:#fffaf0;"></div>


==About this Structure==
==See Also==
[[2yin]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YIN OCA].
*[[Dedicator of cytokinesis protein 3D structures|Dedicator of cytokinesis protein 3D structures]]
*[[Rac 3D structures|Rac 3D structures]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Barford, D.]]
[[Category: Large Structures]]
[[Category: Kulkarni, K A.]]
[[Category: Barford D]]
[[Category: Yang, J.]]
[[Category: Kulkarni KA]]
[[Category: Zhang, Z.]]
[[Category: Yang J]]
[[Category: Zhang Z]]

Latest revision as of 08:14, 23 August 2023

STRUCTURE OF THE COMPLEX BETWEEN Dock2 AND Rac1.

2yin, resolution 2.70Å

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