3mj0: Difference between revisions
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==Crystal Structure of Drosophia Ago-PAZ domain in complex with 3'-end 2'-O-methylated RNA== | |||
<StructureSection load='3mj0' size='340' side='right'caption='[[3mj0]], [[Resolution|resolution]] 2.31Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[3mj0]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MJ0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3MJ0 FirstGlance]. <br> | |||
or | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.306Å</td></tr> | ||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=OMU:O2-METHYLURIDINE+5-MONOPHOSPHATE'>OMU</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3mj0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mj0 OCA], [https://pdbe.org/3mj0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3mj0 RCSB], [https://www.ebi.ac.uk/pdbsum/3mj0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3mj0 ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/AGO2_DROME AGO2_DROME] Essential for RNA interference (RNAi); double-stranded RNA induces potent and specific gene silencing. RNAi is mediated by the RNA-induced silencing complex (RISC), a sequence-specific, multicomponent nuclease that destroys or silences messenger RNAs homologous to the silencing trigger.<ref>PMID:11498593</ref> | |||
== | ==See Also== | ||
*[[Argonaute 3D structures|Argonaute 3D structures]] | |||
== References == | |||
== | <references/> | ||
__TOC__ | |||
</StructureSection> | |||
[[Category: Drosophila melanogaster]] | [[Category: Drosophila melanogaster]] | ||
[[Category: Ding | [[Category: Large Structures]] | ||
[[Category: Huang | [[Category: Ding L]] | ||
[[Category: Ma | [[Category: Huang Y]] | ||
[[Category: Ma J]] | |||
Latest revision as of 08:54, 6 September 2023
Crystal Structure of Drosophia Ago-PAZ domain in complex with 3'-end 2'-O-methylated RNA
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