3gre: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older edit
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,330,058 edits
No edit summary
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,330,058 edits
No edit summary
 
(7 intermediate revisions by the same user not shown)
Line 1: Line 1:
[[Image:3gre.png|left|200px]]


<!--
==Crystal structure of Saccharomyces cerevisiae Vps15 WD repeat domain==
The line below this paragraph, containing "STRUCTURE_3gre", creates the "Structure Box" on the page.
<StructureSection load='3gre' size='340' side='right'caption='[[3gre]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[3gre]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GRE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3GRE FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
-->
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3gre FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gre OCA], [https://pdbe.org/3gre PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3gre RCSB], [https://www.ebi.ac.uk/pdbsum/3gre PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3gre ProSAT]</span></td></tr>
{{STRUCTURE_3gre| PDB=3gre |  SCENE= }}
</table>
== Function ==
[https://www.uniprot.org/uniprot/VPS15_YEAST VPS15_YEAST] Serine/threonine-protein kinase required for cytoplasm to vacuole transport (Cvt) and autophagy as a part of the autophagy-specific VPS34 PI3-kinase complex I. This complex is essential to recruit the ATG8-phosphatidylinositol conjugate and the ATG12-ATG5 conjugate to the pre-autophagosomal structure. Is also involved in endosome-to-Golgi retrograde transport as part of the VPS34 PI3-kinase complex II. This second complex is required for the endosome-to-Golgi retrieval of PEP1 and KEX2, and the recruitment of VPS5 and VPS7, two components of the retromer complex, to endosomal membranes (probably through the synthesis of a specific pool of phosphatidylinositol 3-phosphate recruiting the retromer to the endosomes). By regulating VPS34 kinase activity, VPS15 appears to be essential for the efficient delivery of soluble hydrolases to the yeast vacuole.<ref>PMID:1988155</ref> <ref>PMID:3062374</ref> <ref>PMID:1756716</ref> <ref>PMID:8387919</ref> <ref>PMID:8509446</ref> <ref>PMID:7989323</ref> <ref>PMID:8649377</ref> <ref>PMID:11157979</ref> <ref>PMID:12244127</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gr/3gre_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3gre ConSurf].
<div style="clear:both"></div>


===Crystal structure of Saccharomyces cerevisiae Vps15 WD repeat domain===
==See Also==
 
*[[Serine/threonine protein kinase 3D structures|Serine/threonine protein kinase 3D structures]]
 
*[[Vacuolar protein sorting-associated protein 3D structures|Vacuolar protein sorting-associated protein 3D structures]]
<!--
== References ==
The line below this paragraph, {{ABSTRACT_PUBMED_19445518}}, adds the Publication Abstract to the page
<references/>
(as it appears on PubMed at http://www.pubmed.gov), where 19445518 is the PubMed ID number.
__TOC__
-->
</StructureSection>
{{ABSTRACT_PUBMED_19445518}}
[[Category: Large Structures]]
 
==About this Structure==
[[3gre]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GRE OCA].
 
==Reference==
<ref group="xtra">PMID:019445518</ref><references group="xtra"/>
[[Category: Non-specific serine/threonine protein kinase]]
[[Category: Saccharomyces cerevisiae]]
[[Category: Saccharomyces cerevisiae]]
[[Category: Betts, L.]]
[[Category: Betts L]]
[[Category: Sondek, J.]]
[[Category: Sondek J]]
[[Category: Vanhooke, J L.]]
[[Category: Vanhooke JL]]
[[Category: Atp-binding]]
[[Category: Endosome]]
[[Category: Golgi apparatus]]
[[Category: Kinase]]
[[Category: Lipoprotein]]
[[Category: Membrane]]
[[Category: Myristate]]
[[Category: Nucleotide-binding]]
[[Category: Phosphoprotein]]
[[Category: Protein binding]]
[[Category: Protein transport]]
[[Category: Scaffold protein]]
[[Category: Serine/threonine-protein kinase]]
[[Category: Seven-bladed propeller]]
[[Category: Signaling protein]]
[[Category: Transferase]]
[[Category: Transport]]
[[Category: Wd repeat]]
Retrieved from "https://proteopedia.org/3gre"