|
|
| (41 intermediate revisions by 3 users not shown) |
| Line 1: |
Line 1: |
| [[Image:3hei.png|left|200px|thumb|Crystal Structure of ephrin receptor, [[3hei]]]]
| | <StructureSection load='' size='350' side='right' scene='45/450911/Cv/1' caption='Human ephrin A3 receptor (magenta) complex with peptide substrate (green), nucleotide derivative and Mg+2 ion [[3fxx]]'> |
| {{STRUCTURE_3hei| PDB=3hei | SIZE=300| SCENE=Cadherin/Cv/1 |right|CAPTION=Human ephrin A2 receptor ligand-binding domain complex with ephrin A1, [[3hei]] }}
| |
|
| |
|
| '''Ephrin receptors''' (EPH) are components of the cell signaling pathways. They belong to the receptor tyrosine kinases. The extracellular ligand-binding domain (LBD) interacts with ephrin. EPH contains a sterile-α-motif (SAM) domain and a second fibronectin III domain (fn3).
| | == Function == |
|
| |
|
| {{TOC limit|limit=2}}
| | '''Ephrin receptors''' (EPHR) are components of the cell signaling pathways. They belong to the [[receptor tyrosine kinases]]. The extracellular ligand-binding domain (LBD) interacts with ephrin<ref>PMID:21078817</ref>. |
| | *'''Ephrin receptor A2''' functions in entry of Epstein-Barr virus to epithelial cells<ref>PMID:29292384</ref>. |
| | *'''Ephrin receptor A4''' functions in entry of Kaposi's sarcoma-associated herpesvirus to cells<ref>PMID:30782663</ref>. |
| | *'''Ephrin receptor A5''' is expressed in the nervous system and plays a role in synaptogenesis<ref>PMID:20824214</ref>. |
| | *'''Ephrin receptor A7''' functions in corticogenesis<ref>PMID:34176129</ref>. |
| | *'''Ephrin receptor A8''' has a role in short-range contact-mediated axonal guidance. |
| | *'''Ephrin receptor B4''' determine the molecular distinction between veins and arteries in the early embryo<ref>PMID:26817610</ref>. |
| | *'''Ephrin receptor B6''' functions in cold immune microenvironment and promotes the immune escape in BLCA<ref>PMID:37637034</ref>. |
| | For more details see [[Ephrin Type-A Receptor]] and [[Kinase-linked, enzyme-linked and related receptors]]. |
| | . |
|
| |
|
| | ==Relevance == |
|
| |
|
| | EPHR and ephrins can act as both tumor suppressors and tumor enhancers depending on the context<ref>PMID:20810264</ref>. |
|
| |
|
| | == Structural highlights == |
|
| |
|
| == 3D Structures of ephrin receptors ==
| | EPHR domains include an ectodomain (residues 23-435) containing the LBD (residues 23-326), a second fibronectin III domain (fn3) (residues 446-539), a transmembrane domain (residues 539-563), a kinase domain (residues 596-900) and a sterile-α-motif (SAM) domain (residues 908-972). |
|
| |
|
| ===Ephrin A1 receptor===
| | <scene name='45/450911/Cv/8'>Ephrin A3 receptor with peptide substrate, nucleotide derivative and Mg+2 ion</scene>. Water molecules are shown as red spheres. |
| [[3kka]] - hEPH A1 SAM+ hEPH A2 SAM – human<BR />
| |
| [[2k1l]] - hEPH A1 transmembrane domain – NMR<BR />
| |
| [[1x5a]] - hEPH A1 fn3 domain – NMR<BR />
| |
| ===Ephrin A2 receptor===
| |
| [[3hpn]], [[3c8x]] - hEPH A2 LBD<BR />
| |
| [[2x10]], [[3fl7]] - hEPH A2 ectodomain<BR />
| |
| [[2k9y]], [[3e8n]] - hEPH A2 transmembrane domain – NMR<BR />
| |
| [[1mqb]] - hEPH A2 kinase domain<BR />
| |
| [[3mx0]], [[1x11]] - hEPH A2 ectodomain + ephrin A5<BR />
| |
| [[3hei]], [[3czu]] - hEPH A2 LBD + ephrin A1<BR />
| |
| [[3mbw]] - hEPH A2 LBD + carbohydrate-recognition domain + ephrin A1
| |
| ===Ephrin A3 receptor===
| |
| [[2qo2]], [[2qob]], [[2gsf]] - hEPH A3 kinase domain<BR />
| |
| [[2qok]], [[2qol]], [[2qon]], [[2qoo]], [[2qod]], [[2qof]], [[2qoi]] - hEPH A3 kinase domain (mutant) <BR />
| |
| [[3fxx]], [[3fy2]] – hEPH A3 kinase domain + peptide substrate<BR />
| |
| [[2qoq]], [[2qo7]], [[2qo9]], [[2qoc]] - hEPH A3 kinase domain + AMP-PNP<BR />
| |
| [[3dzq]] - hEPH A3 kinase domain + inhibitor
| |
| ===Ephrin A4 receptor===
| |
| [[2wo1]], [[3ckh]] - hEPH A4 LBD<BR />
| |
| [[2wo3]] - hEPH A4 LBD + ephrin A2 receptor-binding domain<BR />
| |
| [[2wo2]], [[3gxu]] - hEPH A4 LBD + ephrin B2 receptor-binding domain
| |
| ===Ephrin A5 receptor===
| |
| [[2r2p]] - hEPH A5 kinase domain<BR />
| |
| [[1shx]] - mEPH A5 – mouse
| |
| ===Ephrin A7 receptor===
| |
| [[3nru]] – hEPH A7 LBD<BR />
| |
| [[3h8m]] – hEPH A7 SAM<BR />
| |
| [[2rei]] - hEPH A7 kinase domain<BR />
| |
| [[3dko]] – hEPH A7 kinase domain + inhibitor
| |
| ===Ephrin A8 receptor===
| |
| [[3kul]] - hEPH A8 kinase domain<BR />
| |
| [[1x5l]] – hEPH A8 fn3 domain – NMR<BR />
| |
| [[1ucv]] - hEPH A8 SAM – NMR<BR />
| |
| ===Ephrin B1 receptor===
| |
| [[2eao]] – hEPH B1 SAM – NMR<BR />
| |
| [[2djs]] - hEPH B1 fn3 domain – NMR<BR />
| |
| ===Ephrin B2 receptor===
| |
| [[3etp]] – hEPH B2<BR />
| |
| [[1f0m]] – mEPH B2 SAM<BR />
| |
| [[1sgg]] - mEPH B2 SAM – chicken - NMR<BR />
| |
| [[2vsk]], [[2vsm]] – hEPH B2 + Viral Hemagglutinin-neuraminidase<BR />
| |
| [[2qbx]] – hEPH B2 + peptide agonist<BR />
| |
| [[2hen]] - hEPH B2 kinase domain + ADP<BR />
| |
| [[1shw]] - mEPH B2 LBD + ephrin A5<BR />
| |
| [[1kgy]] - mEPH B2 LBD + ephrin B2 extracellular domain<BR />
| |
| [[1iko]] - mEPH B2 ectodomain
| |
|
| |
|
| ===Ephrin B3 receptor===
| | <scene name='45/450911/Cv/9'>Nucleotide derivative and Mg+2 ion binding site</scene>. |
| [[3p1i]] – hEPH B3 LBD<BR />
| |
| ===Ephrin B4 receptor=== | |
| [[2qkq]] – hEPH B4 SAM<BR />
| |
| [[2e7h]] – hEPH B4 fn3 domain - NMR<BR />
| |
| [[2x9f]] - hEPH B4 kinase domain (mutant) <BR />
| |
| [[2vwx]], [[2vwz]], [[2vx0]], [[2vx1]], [[2vwu]], [[2vwv]], [[2vww]] – hEPH B4 + inhibitor <BR />
| |
| [[2hle]], [[2bba]] - hEPH B4 LBD + ephrin B2
| |
|
| |
|
| | <scene name='45/450911/Cv/10'>Peptide substrate binding site</scene> ([[3fxx]]).<ref>PMID:19678838</ref> |
|
| |
|
| | == 3D Structures of ephrin receptor == |
| | [[Ephrin receptor 3D structures]] |
|
| |
|
| | </StructureSection> |
|
| |
|
|
| | == References == |
| | | <references/> |
|
| |
|
| [[Category:Topic Page]] | | [[Category:Topic Page]] |
