3sad: Difference between revisions
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New page: '''Unreleased structure''' The entry 3sad is ON HOLD Authors: Krieger, I.V., Sun, Q., Sacchettini, J.C., Mycobacterium Tuberculosis Structural Proteomics Project (XMTB) Description: Cr... |
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==Crystal structure of Mycobacterium tuberculosis malate synthase in complex with 4-(2-mehtylphenyl)-2,4-dioxobutanoic acid inhibitor== | |||
<StructureSection load='3sad' size='340' side='right'caption='[[3sad]], [[Resolution|resolution]] 1.82Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[3sad]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SAD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3SAD FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.82Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=040:4-(2-METHYLPHENYL)-2,4-DIOXOBUTANOIC+ACID'>040</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3sad FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3sad OCA], [https://pdbe.org/3sad PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3sad RCSB], [https://www.ebi.ac.uk/pdbsum/3sad PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3sad ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/MASZ_MYCTU MASZ_MYCTU] Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA (By similarity).[HAMAP-Rule:MF_00641] | |||
==See Also== | |||
*[[Malate synthase 3D structures|Malate synthase 3D structures]] | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Mycobacterium tuberculosis]] | |||
[[Category: Krieger IV]] | |||
[[Category: Sacchettini JC]] | |||
[[Category: Sun Q]] | |||
Latest revision as of 12:51, 14 March 2024
Crystal structure of Mycobacterium tuberculosis malate synthase in complex with 4-(2-mehtylphenyl)-2,4-dioxobutanoic acid inhibitor
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