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New page: left|200px<br /><applet load="2dza" size="350" color="white" frame="true" align="right" spinBox="true" caption="2dza, resolution 1.90Å" /> '''Crystal Structure of...
 
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[[Image:2dza.gif|left|200px]]<br /><applet load="2dza" size="350" color="white" frame="true" align="right" spinBox="true"
caption="2dza, resolution 1.90&Aring;" />
'''Crystal Structure of Dihydropteroate Synthase from Thermus thermophilus HB8 in Complex with 4-aminobenzoate'''<br />


==About this Structure==
==Crystal Structure of Dihydropteroate Synthase from Thermus thermophilus HB8 in Complex with 4-aminobenzoate==
2DZA is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus] with <scene name='pdbligand=PAB:'>PAB</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Dihydropteroate_synthase Dihydropteroate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.15 2.5.1.15] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DZA OCA].
<StructureSection load='2dza' size='340' side='right'caption='[[2dza]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
[[Category: Dihydropteroate synthase]]
== Structural highlights ==
[[Category: Single protein]]
<table><tr><td colspan='2'>[[2dza]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermus_thermophilus_HB8 Thermus thermophilus HB8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DZA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2DZA FirstGlance]. <br>
[[Category: Thermus thermophilus]]
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
[[Category: Bagautdinov, B.]]
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PAB:4-AMINOBENZOIC+ACID'>PAB</scene></td></tr>
[[Category: Kunishima, N.]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2dza FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dza OCA], [https://pdbe.org/2dza PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2dza RCSB], [https://www.ebi.ac.uk/pdbsum/2dza PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2dza ProSAT], [https://www.topsan.org/Proteins/RSGI/2dza TOPSAN]</span></td></tr>
[[Category: RSGI, RIKEN.Structural.Genomics/Proteomics.Initiative.]]
</table>
[[Category: PAB]]
== Function ==
[[Category: 4-aminobenzoate]]
[https://www.uniprot.org/uniprot/Q5SLV2_THET8 Q5SLV2_THET8] DHPS catalyzes the formation of the immediate precursor of folic acid.[RuleBase:RU361205]
[[Category: dihydropteroate synthase]]
== Evolutionary Conservation ==
[[Category: dimer]]
[[Image:Consurf_key_small.gif|200px|right]]
[[Category: national project on protein structural and functional analyses]]
Check<jmol>
[[Category: nppsfa]]
  <jmolCheckbox>
[[Category: riken structural genomics/proteomics initiative]]
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dz/2dza_consurf.spt"</scriptWhenChecked>
[[Category: rsgi]]
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
[[Category: structural genomics]]
    <text>to colour the structure by Evolutionary Conservation</text>
[[Category: x-ray diffraction]]
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2dza ConSurf].
<div style="clear:both"></div>


''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jan 29 19:14:59 2008''
==See Also==
*[[Dihydropteroate synthase 3D structures|Dihydropteroate synthase 3D structures]]
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Thermus thermophilus HB8]]
[[Category: Bagautdinov B]]
[[Category: Kunishima N]]

Latest revision as of 08:32, 25 October 2023

Crystal Structure of Dihydropteroate Synthase from Thermus thermophilus HB8 in Complex with 4-aminobenzoate

2dza, resolution 1.90Å

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