3nzm: Difference between revisions

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[[Image:3nzm.jpg|left|200px]]


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==Crystal structure of DNAE intein with N-extein in redox trap==
The line below this paragraph, containing "STRUCTURE_3nzm", creates the "Structure Box" on the page.
<StructureSection load='3nzm' size='340' side='right'caption='[[3nzm]], [[Resolution|resolution]] 1.55&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[3nzm]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Synechocystis_sp._PCC_6803 Synechocystis sp. PCC 6803]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NZM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3NZM FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.55&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SNN:L-3-AMINOSUCCINIMIDE'>SNN</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
{{STRUCTURE_3nzm|  PDB=3nzm  |  SCENE= }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3nzm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3nzm OCA], [https://pdbe.org/3nzm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3nzm RCSB], [https://www.ebi.ac.uk/pdbsum/3nzm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3nzm ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/DPO3A_SYNY3 DPO3A_SYNY3]
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Here we describe self-splicing proteins, called inteins, that function as redox-responsive switches in bacteria. Redox regulation was achieved by engineering a disulfide bond between the intein's catalytic cysteine and a cysteine in the flanking 'extein' sequence. This interaction was validated by an X-ray structure, which includes a transient splice junction. A natural analog of the designed system was identified in Pyrococcus abyssi, suggesting an unprecedented form of adaptive, post-translational regulation.


===Crystal structure of DNAE intein with N-extein in redox trap===
Structure of catalytically competent intein caught in a redox trap with functional and evolutionary implications.,Callahan BP, Topilina NI, Stanger MJ, Van Roey P, Belfort M Nat Struct Mol Biol. 2011 May;18(5):630-3. Epub 2011 Apr 3. PMID:21460844<ref>PMID:21460844</ref>


 
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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(as it appears on PubMed at http://www.pubmed.gov), where 21460844 is the PubMed ID number.
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{{ABSTRACT_PUBMED_21460844}}
 
==About this Structure==
[[3nzm]] is a 1 chain structure of [[DNA polymerase]] with sequence from [http://en.wikipedia.org/wiki/Synechocystis_sp._pcc_6803 Synechocystis sp. pcc 6803]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NZM OCA].


==See Also==
==See Also==
*[[DNA polymerase]]
*[[DNA polymerase 3D structures|DNA polymerase 3D structures]]
 
== References ==
==Reference==
<references/>
<ref group="xtra">PMID:021460844</ref><references group="xtra"/>
__TOC__
[[Category: DNA-directed DNA polymerase]]
</StructureSection>
[[Category: Synechocystis sp. pcc 6803]]
[[Category: Large Structures]]
[[Category: Belfort, M.]]
[[Category: Synechocystis sp. PCC 6803]]
[[Category: Callahan, B P.]]
[[Category: Belfort M]]
[[Category: Roey, P Van.]]
[[Category: Callahan BP]]
[[Category: Disulfide bond]]
[[Category: Van Roey P]]
[[Category: Transferase]]

Latest revision as of 09:24, 6 September 2023

Crystal structure of DNAE intein with N-extein in redox trap

3nzm, resolution 1.55Å

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