3r5r: Difference between revisions

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'''Unreleased structure'''


The entry 3r5r is ON HOLD  until Paper Publication
==Structure of Ddn, the Deazaflavin-dependent nitroreductase from Mycobacterium tuberculosis involved in bioreductive activation of PA-824, with co-factor F420==
<StructureSection load='3r5r' size='340' side='right'caption='[[3r5r]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[3r5r]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3R5R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3R5R FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.101&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=F42:COENZYME+F420'>F42</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3r5r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3r5r OCA], [https://pdbe.org/3r5r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3r5r RCSB], [https://www.ebi.ac.uk/pdbsum/3r5r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3r5r ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/DDN_MYCTU DDN_MYCTU] Nitroreductase involved in the bioreductive activation of the antitubercular prodrug PA-824 (nitroimidazo-oxazine) developed for anti-tuberculosis therapy against both replicating and persistent bacteria. It converts PA-824 into three primary metabolites; the major one is the des-nitroimidazole (des-nitro) which generated reactive nitrogen species, including nitric oxide (NO). Reactive nitrogen species play a major role in mammalian defense against mycobacterial infections.<ref>PMID:16387854</ref> <ref>PMID:19039139</ref>


Authors: Cellitti, S.E., Shaffer, J., Jones, D.H., Mukherjee, T., Gurumurthy, M., Bursulaya, B., Boshoff, H.I.M., Choi, I., Nayya, A., Lee, Y.S., Cherian, J., Niyomrattanakit, P., Dick, T., Manjunatha, U.H., Barry, C.E., Spraggon, G., Geierstanger, B.H.
==See Also==
 
*[[Nitroreductase 3D structures|Nitroreductase 3D structures]]
Description: Structure of Ddn, the Deazaflavin-dependent nitroreductase from Mycobacterium tuberculosis involved in bioreductive activation of PA-824, with co-factor F420
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Mycobacterium tuberculosis]]
[[Category: Barry CE]]
[[Category: Boshoff HIM]]
[[Category: Bursulaya B]]
[[Category: Cellitti SE]]
[[Category: Cherian J]]
[[Category: Choi I]]
[[Category: Dick T]]
[[Category: Geierstanger BH]]
[[Category: Gurumurthy M]]
[[Category: Jones DH]]
[[Category: Lee YS]]
[[Category: Manjunatha UH]]
[[Category: Mukherjee T]]
[[Category: Nayya A]]
[[Category: Niyomrattanakit P]]
[[Category: Shaffer J]]
[[Category: Spraggon G]]
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