3sff: Difference between revisions
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New page: '''Unreleased structure''' The entry 3sff is ON HOLD Authors: Stams, T., Vash, B. Description: Crystal Structure of Human HDAC8 Inhibitor Complex, an Amino Acid Derived Inhibitor |
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==Crystal Structure of Human HDAC8 Inhibitor Complex, an Amino Acid Derived Inhibitor== | |||
<StructureSection load='3sff' size='340' side='right'caption='[[3sff]], [[Resolution|resolution]] 2.00Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[3sff]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SFF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3SFF FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0DI:(2R)-2-AMINO-3-(3-CHLOROPHENYL)-1-[4-(2,5-DIFLUOROBENZOYL)PIPERAZIN-1-YL]PROPAN-1-ONE'>0DI</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3sff FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3sff OCA], [https://pdbe.org/3sff PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3sff RCSB], [https://www.ebi.ac.uk/pdbsum/3sff PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3sff ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/HDAC8_HUMAN HDAC8_HUMAN] Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. May play a role in smooth muscle cell contractility.<ref>PMID:10748112</ref> <ref>PMID:10926844</ref> <ref>PMID:10922473</ref> <ref>PMID:14701748</ref> | |||
==See Also== | |||
*[[Histone deacetylase 3D structures|Histone deacetylase 3D structures]] | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Stams T]] | |||
[[Category: Vash B]] | |||
Latest revision as of 09:50, 1 March 2024
Crystal Structure of Human HDAC8 Inhibitor Complex, an Amino Acid Derived Inhibitor
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