3shw: Difference between revisions
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==Crystal structure of ZO-1 PDZ3-SH3-Guk supramodule complex with Connexin-45 peptide== | |||
<StructureSection load='3shw' size='340' side='right'caption='[[3shw]], [[Resolution|resolution]] 2.90Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[3shw]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SHW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3SHW FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.9Å</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3shw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3shw OCA], [https://pdbe.org/3shw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3shw RCSB], [https://www.ebi.ac.uk/pdbsum/3shw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3shw ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/ZO1_HUMAN ZO1_HUMAN] The N-terminal may be involved in transducing a signal required for tight junction assembly, while the C-terminal may have specific properties of tight junctions. The alpha domain might be involved in stabilizing junctions. Plays a role in the regulation of cell migration by targeting CDC42BPB to the leading edge of migrating cells.<ref>PMID:21240187</ref> | |||
==See Also== | |||
*[[Connexin 3D structure|Connexin 3D structure]] | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Chen J]] | |||
[[Category: Pan L]] | |||
[[Category: Yu H]] | |||
[[Category: Yu J]] | |||
[[Category: Zhang M]] | |||
Latest revision as of 08:36, 20 March 2024
Crystal structure of ZO-1 PDZ3-SH3-Guk supramodule complex with Connexin-45 peptide
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