Plectin: Difference between revisions

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<Structure load='1sh6' size='500' frame='true' align='right' caption='Insert caption here' scene='Insert optional scene name here' /><!--
<StructureSection load='1sh6' size='400' caption='Mouse plectin actin-binding domain [[1sh6]]' scene= '>
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== Function == 
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'''Plectin''', a universal and functionally versatile cytolinker protein, can be divided in three main sections; a central coiled-coil rod domain (residues 1492-1530), N and C-terminal globular region and exhibits a dumbbell like structure <ref>PMID:3430617</ref>. C-terminal region is composed of 6 homologous repeating domains (repeat#6 contains residues 4403-4606), and this region has a role in binding to intermediate filaments such as vimentin and cytokeratin<ref>PMID:24810881</ref>, <ref>PMID:24940650</ref>. N-terminal globular region contains actin binding domain (ABD) (residues 175-400) comprising of two calponin homology (CH) domains, plakin domain (residues 300-1372) and N-terminal arm, which varies among isoforms.  
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Plectin, a universal and functionally versatile cytolinker protein, can be divided in three main sections; a central coiled-coil rod domain, N and C-terminal globular region and exhibits a dumbbell like structure (1). C-terminal region is composed of 6 homologous repeating domains, and this region has a role in binding to intermediate filaments such as vimentin and cytokeratin (2). N-terminal globular region contains actin binding domain (ABD) comprising two calponin homology (CH) domains and N-terminal arm, which varies among isoforms (3).  


For more details see [[Group:MUZIC:Plectin]].


1. Foisner, R., and Wiche, G. (1987) J Mol Biol 198, 515-531
==Disease ==
2. Nikolic, B., Mac Nulty, E., Mir, B., and Wiche, G. (1996) J Cell Biol 134, 1455-1467
Mutations in plectin result in skin fragility and blister formation<ref>PMID:15810881</ref>.
3. Fuchs, P., Zorer, M., Rezniczek, G. A., Spazierer, D., Oehler, S., Castanon, M. J., Hauptmann, R., and Wiche, G. (1999) Hum Mol Genet 8, 2461-2472
 
</StructureSection>
==3D structures of plectin==
[[Plectin 3D structures]]
 
== References ==
<references/>
[[Category:Topic Page]]

Latest revision as of 10:39, 27 May 2026

Mouse plectin actin-binding domain 1sh6

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3D structures of plectin

Plectin 3D structures

References

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Jae-Geun Song, Michal Harel, Alexander Berchansky

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