2g9c: Difference between revisions

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New page: left|200px<br /><applet load="2g9c" size="350" color="white" frame="true" align="right" spinBox="true" caption="2g9c, resolution 1.70Å" /> '''Modified pyrimidines...
 
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[[Image:2g9c.gif|left|200px]]<br /><applet load="2g9c" size="350" color="white" frame="true" align="right" spinBox="true"
caption="2g9c, resolution 1.70&Aring;" />
'''Modified pyrimidines Specifically bind the purine riboswitch'''<br />


==Overview==
==Modified pyrimidines Specifically bind the purine riboswitch==
<StructureSection load='2g9c' size='340' side='right'caption='[[2g9c]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2g9c]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2G9C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2G9C FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3AY:PYRIMIDINE-2,4,6-TRIAMINE'>3AY</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=NCO:COBALT+HEXAMMINE(III)'>NCO</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2g9c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2g9c OCA], [https://pdbe.org/2g9c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2g9c RCSB], [https://www.ebi.ac.uk/pdbsum/2g9c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2g9c ProSAT]</span></td></tr>
</table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The purine riboswitch is a genetic regulatory element found in the 5'-untranslated regions of Gram-positive bacteria that regulates expression of the mRNA specifically in response to either guanine or adenine. We report that the adenine-responsive RNA element is also capable of specifically recognizing pyrimidine compounds bearing modifications at the 6- or 5,6-positions in a fashion similar to that of purine compounds. Using isothermal titration calorimetry and X-ray crystallography, the binding of these compounds is characterized.
The purine riboswitch is a genetic regulatory element found in the 5'-untranslated regions of Gram-positive bacteria that regulates expression of the mRNA specifically in response to either guanine or adenine. We report that the adenine-responsive RNA element is also capable of specifically recognizing pyrimidine compounds bearing modifications at the 6- or 5,6-positions in a fashion similar to that of purine compounds. Using isothermal titration calorimetry and X-ray crystallography, the binding of these compounds is characterized.


==About this Structure==
Modified pyrimidines specifically bind the purine riboswitch.,Gilbert SD, Mediatore SJ, Batey RT J Am Chem Soc. 2006 Nov 8;128(44):14214-5. PMID:17076468<ref>PMID:17076468</ref>
2G9C is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/ ] with <scene name='pdbligand=ACT:'>ACT</scene>, <scene name='pdbligand=NCO:'>NCO</scene> and <scene name='pdbligand=3AY:'>3AY</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2G9C OCA].


==Reference==
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
Modified pyrimidines specifically bind the purine riboswitch., Gilbert SD, Mediatore SJ, Batey RT, J Am Chem Soc. 2006 Nov 8;128(44):14214-5. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=17076468 17076468]
</div>
[[Category: Protein complex]]
<div class="pdbe-citations 2g9c" style="background-color:#fffaf0;"></div>
[[Category: Batey, R.T.]]
[[Category: Gilbert, S.D.]]
[[Category: Mediatore, S.J.]]
[[Category: 3AY]]
[[Category: ACT]]
[[Category: NCO]]
[[Category: mrna]]
[[Category: riboswitch]]
[[Category: rna-ligand complex]]
[[Category: triaminopyrimidine]]


''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jan 29 19:54:41 2008''
==See Also==
*[[Riboswitch 3D structures|Riboswitch 3D structures]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Bacillus subtilis]]
[[Category: Large Structures]]
[[Category: Batey RT]]
[[Category: Gilbert SD]]
[[Category: Mediatore SJ]]
Retrieved from "https://proteopedia.org/2g9c"