3b0f: Difference between revisions

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[[Image:3b0f.jpg|left|200px]]


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==Crystal structure of the UBA domain of p62 and its interaction with ubiquitin==
The line below this paragraph, containing "STRUCTURE_3b0f", creates the "Structure Box" on the page.
<StructureSection load='3b0f' size='340' side='right'caption='[[3b0f]], [[Resolution|resolution]] 1.40&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)  
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[3b0f]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3B0F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3B0F FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.4&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
{{STRUCTURE_3b0f|  PDB=3b0f  |  SCENE=  }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3b0f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3b0f OCA], [https://pdbe.org/3b0f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3b0f RCSB], [https://www.ebi.ac.uk/pdbsum/3b0f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3b0f ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/SQSTM_MOUSE SQSTM_MOUSE] Required both for the formation and autophagic degradation of polyubiquitin-containing bodies, called ALIS (aggresome-like induced structures). Links ALIS to the autophagic machinery via direct interaction with MAP1 LC3 family members. May regulate the activation of NFKB1 by TNF-alpha, nerve growth factor (NGF) and interleukin-1. May play a role in titin/TTN downstream signaling in muscle cells. May regulate signaling cascades through ubiquitination. May be involved in cell differentiation, apoptosis, immune response and regulation of K(+) channels. Adapter that mediates the interaction between TRAF6 and CYLD.<ref>PMID:14960283</ref> <ref>PMID:18382763</ref>  


===Crystal structure of the UBA domain of p62 and its interaction with ubiquitin===
==See Also==
 
*[[Sequestosome|Sequestosome]]
 
== References ==
==About this Structure==
<references/>
[[3b0f]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3B0F OCA].
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
[[Category: Arita, K.]]
[[Category: Arita K]]
[[Category: Hasegawa, J.]]
[[Category: Hasegawa J]]
[[Category: Isogai, S.]]
[[Category: Isogai S]]
[[Category: Komatsu, M.]]
[[Category: Komatsu M]]
[[Category: Morimoto, D.]]
[[Category: Morimoto D]]
[[Category: Shirakawa, M.]]
[[Category: Shirakawa M]]
[[Category: Sou, Y.]]
[[Category: Sou Y]]
[[Category: Tanaka, K.]]
[[Category: Tanaka K]]
[[Category: Tenno, T.]]
[[Category: Tenno T]]
[[Category: Tochio, H.]]
[[Category: Tochio H]]
[[Category: Unzai, S.]]
[[Category: Unzai S]]
[[Category: Autophagy]]
[[Category: Protein binding]]
[[Category: Ubiquitin]]
Retrieved from "https://proteopedia.org/3b0f"