2ggq: Difference between revisions

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New page: left|200px<br /><applet load="2ggq" size="350" color="white" frame="true" align="right" spinBox="true" caption="2ggq, resolution 2.00Å" /> '''complex of hypotheti...
 
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[[Image:2ggq.gif|left|200px]]<br /><applet load="2ggq" size="350" color="white" frame="true" align="right" spinBox="true"
caption="2ggq, resolution 2.00&Aring;" />
'''complex of hypothetical glucose-1-phosphate thymidylyltransferase from sulfolobus tokodaii'''<br />


==About this Structure==
==complex of hypothetical glucose-1-phosphate thymidylyltransferase from sulfolobus tokodaii==
2GGQ is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Sulfolobus_tokodaii Sulfolobus tokodaii] with <scene name='pdbligand=IOD:'>IOD</scene> and <scene name='pdbligand=TTP:'>TTP</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Glucose-1-phosphate_thymidylyltransferase Glucose-1-phosphate thymidylyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.24 2.7.7.24] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GGQ OCA].
<StructureSection load='2ggq' size='340' side='right'caption='[[2ggq]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
[[Category: Glucose-1-phosphate thymidylyltransferase]]
== Structural highlights ==
[[Category: Single protein]]
<table><tr><td colspan='2'>[[2ggq]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Sulfurisphaera_tokodaii Sulfurisphaera tokodaii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GGQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2GGQ FirstGlance]. <br>
[[Category: Sulfolobus tokodaii]]
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
[[Category: Kuramitsu, S.]]
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene>, <scene name='pdbligand=TTP:THYMIDINE-5-TRIPHOSPHATE'>TTP</scene></td></tr>
[[Category: Masui, R.]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ggq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ggq OCA], [https://pdbe.org/2ggq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ggq RCSB], [https://www.ebi.ac.uk/pdbsum/2ggq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ggq ProSAT]</span></td></tr>
[[Category: Mizushima, T.]]
</table>
[[Category: Rajakannan, V.]]
== Function ==
[[Category: Suzuki, A.]]
[https://www.uniprot.org/uniprot/S1PNA_SULTO S1PNA_SULTO] Bifunctional enzyme involved in the synthesis of UDP-N-acetylglucosamine (UDP-GlcNAc) and UDP-N-acetylgalactosamine (UDP-GalNAc). It has multiple amino-sugar-1-phosphate acetyltransferase activities, including glucosamine-1-phosphate (GlcN-1-P) acetyltransferase and galactosamine-1-phosphate (GalN-1-P) acetyltransferase activities, and multiple sugar-1-phosphate nucleotidylyltransferase activities, including N-acetylglucosamine-1-phosphate (GlcNAc-1-P) uridyltransferase and N-acetylgalactosamine-1-phosphate (GalNAc-1-P) uridyltransferase activities (PubMed:15598657, PubMed:20400541, PubMed:25567746). Also catalyzes the formation of dTDP-glucose from dTTP and glucose-1-phosphate (Glc-1-P), and the reverse reaction, which produces dTTP from dTDP-glucose and diphosphate (PubMed:15598657). Can also catalyze the formation of UDP-glucose from UTP and glucose-1-phosphate (PubMed:27864169, PubMed:30291121).<ref>PMID:15598657</ref> <ref>PMID:20400541</ref> <ref>PMID:25567746</ref> <ref>PMID:27864169</ref> <ref>PMID:30291121</ref>
[[Category: Yamane, T.]]
== Evolutionary Conservation ==
[[Category: IOD]]
[[Image:Consurf_key_small.gif|200px|right]]
[[Category: TTP]]
Check<jmol>
[[Category: beta barrel]]
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gg/2ggq_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2ggq ConSurf].
<div style="clear:both"></div>


''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jan 29 19:58:59 2008''
==See Also==
*[[Glucose-1-phosphate thymidylyltransferase 3D structures|Glucose-1-phosphate thymidylyltransferase 3D structures]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Sulfurisphaera tokodaii]]
[[Category: Kuramitsu S]]
[[Category: Masui R]]
[[Category: Mizushima T]]
[[Category: Rajakannan V]]
[[Category: Suzuki A]]
[[Category: Yamane T]]
Retrieved from "https://proteopedia.org/2ggq"