Lactoferrin: Difference between revisions

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{{STRUCTURE_1blf|  PDB=1blf  | SIZE=300| SCENE= |right|  CAPTION=Bovine lactoferrin with glucosamine, mannose, carbonate and Fe+3, [[1blf]] }}
<StructureSection load='1bka' size='400' side='right' caption='Human lactoferrin complex with oxalate and Fe+3 ion (PDB entry [[1bka]])' scene='45/455488/Cv/1'>


== Function ==
'''Lactoferrin''' or '''lactotransferrin''' (LTF) is found in secretory fluids.  LTF interacts with DNA, RNA, polysaccharides and heparin<ref>PMID:19519436</ref>.  For detailed discussion of human lactoferrin see [[Human lactoferrin]].


== Relevance ==
LTF is inhibited by nonsteroidal anti-inflammatory drugs (NSAID) like aspirin. It is a component of the immune system and has antimicrobial activity<ref>PMID:14568385</ref>.  LTF can be used as a marker for inflammatory bowel disease<ref>PMID:11866274</ref>.


'''Lactoferrin''' (LTF) is found in secretory fluids.  It is a component of the immune system and has antimicrobial activity.  LTF interacts with DNA, RNA, polysaccharides and heparin. LTF is inhibited by nonsteroidal anti-inflammatory drugs (NSAID) like aspirin.
== Structural highlights ==
LTF is a bilobal protein with the <scene name='45/455488/Cv/7'>N-terminal half and the C-terminal half called N-lobe and C-lobe</scene>.  LTF binds with high affinity Fe+3 ion and an anion in both its N-lobe and its C-lobe<ref>PMID:8703903</ref>. The binding site is between the 2 domains of each lobe.  


<scene name='45/455488/Cv/8'>N-lobe binding site</scene>.


The <scene name='45/455488/Cv/9'>anion binds the Fe+3 in a 1,2 bidendate fashion</scene>.


{{TOC limit|limit=2}}
<scene name='45/455488/Cv/10'>C-lobe binding site</scene>.


The <scene name='45/455488/Cv/11'>anion binds the Fe+3 in a 1,2 bidendate fashion</scene>.
</StructureSection>
== 3D Structures of lactoferrin ==
== 3D Structures of lactoferrin ==


Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
{{#tree:id=OrganizedByTopic|openlevels=0|
*Apo lactoferrin
**[[1cb6]], [[1lfg]], [[1lfh]] – hLTF - human<BR />
**[[1u62]], [[1xv4]], [[1xv7]], [[1z6v]], [[1z6w]] - hLTF peptide – NMR<BR />
**[[1i6b]], [[1b7u]] – hoLTF – horse<BR />
**[[1dtz]] – cLTF - camel<BR />
**[[1lfc]] – bLTF residues 17-41 – bovine – NMR<br />
**[[4oqo]] – bLTF C lobe<br />
*Lactoferrin
**[[2bjj]], [[1sqy]], [[1n76]]– hLTF + 2Fe<br />
**[[1b0l]] - hLTF (mutant) + 2Fe<br />
**[[1fck]] – hLTF + 2Ce<BR />
**[[1lfi]] - hLTF + 2Cu<BR />
**[[1lct]] - hLTF N lobe + 2Fe<br />
**[[1h43]], [[1h44]], [[1h45]], [[1l5t]], [[1eh3]], [[1vfd]], [[1vfe]], [[1hse]], [[1dsn]] - hLTF N lobe (mutant) + 2Fe<br />
**[[1blf]] – bLTF + 2Fe <BR />
**[[1sdx]] - bLTF C lobe + 3Zn<BR />
**[[5cry]], [[5hbc]], [[7enu]], [[7equ]], [[7ev0]], [[7evq]], [[7fdw]] - bLTF C lobe + Fe+3<br />
**[[1nkx]], [[3u8q]] - bLTF C lobe + 2Zn + Fe<br />
**[[1b1x]], [[1f9b]] – hoLTF + 2Fe<br />
**[[1qjm]] – hoLTF + 2Sm<BR />
**[[1ce2]], [[1biy]] – buLTF + 2Fe - buffalo<BR />
**[[1i6q]] – cLTF + 2Fe<br />
**[[1jw1]] – LTF + 2Fe – goat
*Lactoferrin complex
**[[1bka]] - hLTF + 2Fe + oxalate<BR />
**[[7jrd]] - hLTF + 2Fe + LTF-binding protein<br />
**[[7n88]] - hLTF + 2Fe + LTF-binding protein – Cryo EM<br />
**[[1lcf]] - hLTF + 2Cu + oxalate<BR />
**[[2pms]] – hLTF N lobe + PSPA transferring-binding domain + 2Zn + 2Fe<br />
**[[3sdf]] – bLTF C lobe + lipoteichoic acid + 2Zn + Fe<br />
**[[4n6p]] - bLTF C lobe + meclofenamic acid + 2Zn + Fe<br />
**[[4ned]] - bLTF C lobe + fenoprofen + 2Zn + Fe<br />
**[[3rgy]] - bLTF C lobe + lipopolysaccharide + Zn + Fe<br />
**[[3kj7]], [[3k0v]], [[2q8j]], [[2o51]], [[2nwj]], [[2dxy]], [[2dwj]], [[2dsf]], [[2ds9]], [[2hca]], [[2dqv]], [[2dp8]], [[2g93]], [[2ays]], [[2alu]], [[2dwi]], [[2dyx]], [[2o1l]], [[2p1s]] - bLTF C lobe + polysaccharide + 2Zn + Fe<br />
**[[2o1l]] - bLTF C lobe + polysaccharide + Zn + Fe<BR />
**[[2fa7]], [[2b65]] - bLTF C lobe + polysaccharide + 3Zn + Fe<BR />
**[[2dvc]], [[2dwa]], [[2dwh]], [[2e0s]], [[2e1s]], [[2h4i]], [[2px1]] - bLTF C lobe + saccharide + 2Zn + Fe<br />
**[[2dxr]] - bLTF C lobe + sorbitol+ 2Zn + Fe<br />
**[[3iaz]], [[3ib0]], [[3ib1]] - bLTF C lobe (mutant) + NSAID + 2Zn + Fe<br />
**[[3e9x]], [[2qje]], [[2zmb]], [[3crb]], [[2nuv]], [[4fim]], [[4fjp]], [[4for]], [[4g2z]], [[4g77]], [[4g8h]], [[4grk]], [[3taj]] - bLTF C lobe + NSAID + 2Zn + Fe<br />
**[[3o97]], [[3mjn]], [[3cfl]], [[2ocu]], [[3tod]], [[3tus]] – bLTF C lobe + inhibitor + 2Zn + Fe<br />
**[[3ib2]] - bLTF C lobe (mutant) + inhibitor + 2Zn + Fe<br />
**[[2doj]] - bLTF C lobe + adenosine + 2Zn + Fe<br />
**[[3ugw]] - bLTF C lobe + deoxycytidine + 2Zn + Fe<br />
**[[3ci8]] - bLTF C lobe + niacin + 2Zn + Fe<br />
**[[2r9j]] - bLTF C lobe + nicotinamide + 2Zn + Fe<br />
**[[2r71]] - bLTF C lobe + inositol + 2Zn + Fe<br />
**[[3uk4]] - bLTF C lobe + pentatriol + 2Zn + Fe<br />
**[[3usd]] - bLTF C lobe + pyridine derivative + 2Zn + Fe<br />
**[[3ttr]] - bLTF C lobe + anasthetic + 2Zn + Fe<br />
**[[3vdf]] - bLTF C lobe + diaminopimelic acid + 2Zn + Fe<br />
**[[4dxu]] - bLTF C lobe + caproic acid + 2Zn + Fe<br />
**[[3v5a]] - bLTF C lobe + γ-amino butyric acid + 2Zn + Fe<br />
**[[3u72]], [[4dig]] - bLTF C lobe + polypeptide + 2Zn + Fe<br />
**[[3ptl]] – bLTF peptide + proteinase K<BR />
**[[1bjr]] - buLTF peptide + proteinase K<BR />
**[[1b7z]] - hoLTF + 2Fe + oxalate<BR />
**[[3cr9]] – hoLTF + inhibitor + 2Fe<br />
**[[2j4u]] – cLTF N terminal + OMPC <BR />
}}
== References ==
<references/>






[[Category:Topic Page]]
[[Category:Topic Page]]
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