2xg3: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older edit
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,331,615 edits
m Protected "2xg3" [edit=sysop:move=sysop]
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,331,615 edits
No edit summary
 
(9 intermediate revisions by the same user not shown)
Line 1: Line 1:
[[Image:2xg3.png|left|200px]]


<!--
==Human galectin-3 in complex with a benzamido-N-acetyllactoseamine inhibitor==
The line below this paragraph, containing "STRUCTURE_2xg3", creates the "Structure Box" on the page.
<StructureSection load='2xg3' size='340' side='right'caption='[[2xg3]], [[Resolution|resolution]] 1.20&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[2xg3]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XG3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XG3 FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.2&#8491;</td></tr>
-->
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=UNU:BENZAMIDE'>UNU</scene></td></tr>
{{STRUCTURE_2xg3|  PDB=2xg3  |  SCENE=  }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xg3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xg3 OCA], [https://pdbe.org/2xg3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xg3 RCSB], [https://www.ebi.ac.uk/pdbsum/2xg3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xg3 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/LEG3_HUMAN LEG3_HUMAN] Galactose-specific lectin which binds IgE. May mediate with the alpha-3, beta-1 integrin the stimulation by CSPG4 of endothelial cells migration. Together with DMBT1, required for terminal differentiation of columnar epithelial cells during early embryogenesis (By similarity). In the nucleus: acts as a pre-mRNA splicing factor. Involved in acute inflammatory responses including neutrophil activation and adhesion, chemoattraction of monocytes macrophages, opsonization of apoptotic neutrophils, and activation of mast cells.<ref>PMID:15181153</ref> <ref>PMID:19594635</ref> <ref>PMID:19616076</ref>  


===HUMAN GALECTIN-3 IN COMPLEX WITH A BENZAMIDO-N-ACETYLLACTOSEAMINE INHIBITOR===
==See Also==
 
*[[Galectin 3D structures|Galectin 3D structures]]
 
== References ==
<!--
<references/>
The line below this paragraph, {{ABSTRACT_PUBMED_20873837}}, adds the Publication Abstract to the page
__TOC__
(as it appears on PubMed at http://www.pubmed.gov), where 20873837 is the PubMed ID number.
</StructureSection>
-->
[[Category: Homo sapiens]]
{{ABSTRACT_PUBMED_20873837}}
[[Category: Large Structures]]
 
[[Category: Akke M]]
==About this Structure==
[[Category: Delaine T]]
[[2xg3]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XG3 OCA].
[[Category: Diehl C]]
 
[[Category: Engstrom O]]
==Reference==
[[Category: Genheden S]]
<ref group="xtra">PMID:020873837</ref><references group="xtra"/>
[[Category: Hakansson M]]
[[Category: Akke, M.]]
[[Category: Leffler H]]
[[Category: Delaine, T.]]
[[Category: Modig K]]
[[Category: Diehl, C.]]
[[Category: Nilsson U]]
[[Category: Engstrom, O.]]
[[Category: Ryde U]]
[[Category: Genheden, S.]]
[[Category: Hakansson, M.]]
[[Category: Leffler, H.]]
[[Category: Modig, K.]]
[[Category: Nilsson, U.]]
[[Category: Ryde, U.]]
[[Category: Ige-binding protein]]
[[Category: Lectin]]
[[Category: Sugar binding protein]]
Retrieved from "https://proteopedia.org/2xg3"