3sk2: Difference between revisions

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'''Unreleased structure'''


The entry 3sk2 is ON HOLD  until Paper Publication
==Crystal structure of phenazine resistance protein EhpR from Enterobacter agglomerans (Erwinia herbicola, Pantoea agglomerans) Eh1087 in complex with griseoluteic acid==
 
<StructureSection load='3sk2' size='340' side='right'caption='[[3sk2]], [[Resolution|resolution]] 1.01&Aring;' scene=''>
Authors: Blankenfeldt, W., Yu, S.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[3sk2]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Pantoea_agglomerans Pantoea agglomerans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SK2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3SK2 FirstGlance]. <br>
Description: Crystal structure of phenazine resistance protein EhpR from Enterobacter agglomerans (Erwinia herbicola, Pantoea agglomerans) Eh1087 in complex with griseoluteic acid
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.01&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GRI:6-FORMYL-9-METHOXYPHENAZINE-1-CARBOXYLIC+ACID'>GRI</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3sk2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3sk2 OCA], [https://pdbe.org/3sk2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3sk2 RCSB], [https://www.ebi.ac.uk/pdbsum/3sk2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3sk2 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/EHPR_ENTAG EHPR_ENTAG] Required for resistance to the phenazine antibiotic D-alanylgriseoluteic acid (AGA), an antibiotic produced by E.agglomerans itself, and thus protects the bacterium against phenazine toxicity. Probably binds AGA and acts as a chaperone that works in tandem with a membrane transporter for subsequent antibiotic secretion.<ref>PMID:12139622</ref> <ref>PMID:21849072</ref>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Pantoea agglomerans]]
[[Category: Blankenfeldt W]]
[[Category: Yu S]]
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