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[[Image:1vt5.jpg|left|200px]]


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==THE CRYSTAL STRUCTURE OF D(CCCCGGGG): A NEW A-FORM VARIANT WITH AN EXTENDED BACKBONE CONFORMATION==
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<StructureSection load='1vt5' size='340' side='right'caption='[[1vt5]], [[Resolution|resolution]] 2.25&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)  
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[1vt5]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VT5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1VT5 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.25&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1vt5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1vt5 OCA], [https://pdbe.org/1vt5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1vt5 RCSB], [https://www.ebi.ac.uk/pdbsum/1vt5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1vt5 ProSAT]</span></td></tr>
{{STRUCTURE_1vt5|  PDB=1vt5  |  SCENE=  }}
</table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The crystal structure of d(CCCCGGGG) has been determined at a resolution of 2.25 A. The oligomers crystallize as A-DNA duplexes occupying crystallographic two-fold axes. The backbone conformation is, in general, similar to that observed in previously reported crystal structures of A-DNA fragments, except for the central linkage, where it adopts an extended structure resulting from all trans conformation at the P-O5'-C5'-C4' bonds. This type of conformation facilitates interstrand stacking between the guanines at the C-G site. The local helix twist at this step is very small (25 degrees) compared to an overall average of 33.5 degrees. The unique structure of the C-G base-pair step, namely the extended backbone and the distinct stacking geometry, may be an important feature in the recognition mechanism between double-stranded DNA molecules and restriction endonucleases such as Msp I, which cuts the sequence CCGG very specifically with a rate unaffected by neighboring base pairs.


===THE CRYSTAL STRUCTURE OF D(CCCCGGGG): A NEW A-FORM VARIANT WITH AN EXTENDED BACKBONE CONFORMATION===
The crystal structure of d(CCCCGGGG): a new A-form variant with an extended backbone conformation.,Haran TE, Shakked Z, Wang AH, Rich A J Biomol Struct Dyn. 1987 Oct;5(2):199-217. PMID:3271472<ref>PMID:3271472</ref>


 
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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<div class="pdbe-citations 1vt5" style="background-color:#fffaf0;"></div>
(as it appears on PubMed at http://www.pubmed.gov), where 3271472 is the PubMed ID number.
== References ==
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<references/>
{{ABSTRACT_PUBMED_3271472}}
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</StructureSection>
==About this Structure==
[[Category: Large Structures]]
[[1vt5]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VT5 OCA].
[[Category: Haran TE]]
 
[[Category: Rich A]]
==Reference==
[[Category: Shakked Z]]
<ref group="xtra">PMID:003271472</ref><ref group="xtra">PMID:006955784</ref><references group="xtra"/>
[[Category: Wang AH-J]]
[[Category: Haran, T E.]]
[[Category: Rich, A.]]
[[Category: Shakked, Z.]]
[[Category: Wang, A H.J.]]
[[Category: A-dna]]
[[Category: Dna]]
[[Category: Double helix]]
Retrieved from "https://proteopedia.org/1vt5"