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New page: left|200px<br /><applet load="2ho6" size="350" color="white" frame="true" align="right" spinBox="true" caption="2ho6, resolution 2.80Å" /> '''Post-cleavage state ...
 
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[[Image:2ho6.gif|left|200px]]<br /><applet load="2ho6" size="350" color="white" frame="true" align="right" spinBox="true"
caption="2ho6, resolution 2.80&Aring;" />
'''Post-cleavage state of the Thermoanaerobacter tengcongensis glmS ribozyme'''<br />


==Overview==
==Post-cleavage state of the Thermoanaerobacter tengcongensis glmS ribozyme==
The glmS ribozyme is the only natural catalytic RNA known to require a, small-molecule activator for catalysis. This catalytic RNA functions as a, riboswitch, with activator-dependent RNA cleavage regulating glmS, messenger RNA expression. We report crystal structures of the glmS, ribozyme in precleavage states that are unliganded or bound to the, competitive inhibitor glucose-6-phosphate and in the postcleavage state., All structures superimpose closely, revealing a remarkably rigid RNA that, contains a preformed active and coenzyme-binding site. Unlike other, riboswitches, the glmS ribozyme binds its activator in an open, solvent-accessible pocket. Our structures suggest that the amine group of, the glmS ribozyme-bound coenzyme performs general acid-base and, electrostatic catalysis.
<StructureSection load='2ho6' size='340' side='right'caption='[[2ho6]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2ho6]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Caldanaerobacter_subterraneus_subsp._tengcongensis Caldanaerobacter subterraneus subsp. tengcongensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HO6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2HO6 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A23:ADENOSINE-5-PHOSPHATE-2,3-CYCLIC+PHOSPHATE'>A23</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ho6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ho6 OCA], [https://pdbe.org/2ho6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ho6 RCSB], [https://www.ebi.ac.uk/pdbsum/2ho6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ho6 ProSAT]</span></td></tr>
</table>


==About this Structure==
==See Also==
2HO6 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/ ] with <scene name='pdbligand=MG:'>MG</scene> and <scene name='pdbligand=MES:'>MES</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HO6 OCA].
*[[Ribozyme 3D structures|Ribozyme 3D structures]]
 
__TOC__
==Reference==
</StructureSection>
Structural basis of glmS ribozyme activation by glucosamine-6-phosphate., Klein DJ, Ferre-D'Amare AR, Science. 2006 Sep 22;313(5794):1752-6. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16990543 16990543]
[[Category: Caldanaerobacter subterraneus subsp. tengcongensis]]
[[Category: Protein complex]]
[[Category: Large Structures]]
[[Category: Amare, A.R.Ferre-D.]]
[[Category: Ferre-D'Amare AR]]
[[Category: Klein, D.J.]]
[[Category: Klein DJ]]
[[Category: MES]]
[[Category: MG]]
[[Category: rna; ribozyme; pseudoknot; helix]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jan 29 20:25:15 2008''

Latest revision as of 09:33, 14 February 2024

Post-cleavage state of the Thermoanaerobacter tengcongensis glmS ribozyme

2ho6, resolution 2.80Å

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