2ygc: Difference between revisions

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[[Image:2ygc.jpg|left|200px]]


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==Structure of vaccinia virus D13 scaffolding protein==
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<StructureSection load='2ygc' size='340' side='right'caption='[[2ygc]], [[Resolution|resolution]] 3.02&Aring;' scene=''>
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== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[2ygc]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Vaccinia_virus_Western_Reserve Vaccinia virus Western Reserve]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YGC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2YGC FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.02&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
{{STRUCTURE_2ygc|  PDB=2ygc  |  SCENE=  }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ygc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ygc OCA], [https://pdbe.org/2ygc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ygc RCSB], [https://www.ebi.ac.uk/pdbsum/2ygc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ygc ProSAT]</span></td></tr>
</table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The morphogenesis of poxviruses such as vaccinia virus (VACV) sees the virion shape mature from spherical to brick-shaped. Trimeric capsomers of the VACV D13 protein form a transitory, stabilizing lattice on the surface of the initial spherical immature virus particle. The crystal structure of D13 reveals that this major scaffolding protein comprises a double beta barrel "jelly-roll" subunit arranged as pseudo-hexagonal trimers. These structural features are characteristic of the major capsid proteins of a lineage of large icosahedral double-stranded DNA viruses including human adenovirus and the bacteriophages PRD1 and PM2. Structure-based phylogenetic analysis confirms that VACV belongs to this lineage, suggesting that (analogously to higher organism embryogenesis) early poxvirus morphogenesis reflects their evolution from a lineage of viruses sharing a common icosahedral ancestor.


===STRUCTURE OF VACCINIA VIRUS D13 SCAFFOLDING PROTEIN===
Insights into the evolution of a complex virus from the crystal structure of vaccinia virus d13.,Bahar MW, Graham SC, Stuart DI, Grimes JM Structure. 2011 Jul 13;19(7):1011-20. PMID:21742267<ref>PMID:21742267</ref>


 
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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== References ==
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<references/>
{{ABSTRACT_PUBMED_21742267}}
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</StructureSection>
==About this Structure==
[[Category: Large Structures]]
[[2ygc]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Vaccinia_virus Vaccinia virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YGC OCA].
[[Category: Vaccinia virus Western Reserve]]
 
[[Category: Bahar MW]]
==Reference==
[[Category: Graham SC]]
<ref group="xtra">PMID:021742267</ref><references group="xtra"/>
[[Category: Grimes JM]]
[[Category: Vaccinia virus]]
[[Category: Stuart DI]]
[[Category: Bahar, M W.]]
[[Category: Graham, S C.]]
[[Category: Grimes, J M.]]
[[Category: Stuart, D I.]]
[[Category: Viral evolution]]
[[Category: Viral protein]]

Latest revision as of 01:32, 21 November 2024

Structure of vaccinia virus D13 scaffolding protein

2ygc, resolution 3.02Å

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