M2 protein: Difference between revisions
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Michal Harel (talk | contribs) New page: {{STRUCTURE_2kj1| PDB=2kj1 | SIZE=300| SCENE= |right| CAPTION=NMR structure of cytoplasmic domain of M2 protein from influenza B virus, 2kj1 }} The '''M2 protein''' (M2) is a pro... |
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<StructureSection load='4c3e' size='350' side='right' caption='Human respiratory syncytial virus M2 protein complex with Zn+2 ions (grey) (PDB entry [[4c3e]])' scene='45/458472/Cv/1'> | |||
__TOC__ | |||
== Function == | |||
The '''M2 protein''' or '''Matrix protein 2''' (M2) is a proton selective ion channel of the influenza virus<ref>PMID:18045172</ref>. It is activated by low pH. M2 has 3 domains: an ectodomain, transmembrane domain (TM) and a C terminal cytoplasmic domain. See more in:<br /> | |||
[[M2 Proton Channel]]<br /> | |||
[[Molecular Playground/Influenza A M2 transmembrane domain]]<br /> | |||
[[M2 Proton Channel Inhibitor Pharmacokinetics]]. | |||
== Structural highlights == | |||
M2 protein from Human respiratory syncytial virus contains 4 domains: Zn-binding, transmembrane (TM), core which binds RNA and a C terminal domain<ref>PMID:24434552</ref>. <scene name='45/458472/Cv/3'>Zn binding site</scene>. | |||
==3D structures of M2 protein== | ==3D structures of M2 protein== | ||
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | |||
[[3bkd]], [[4qk7]], [[4qkc]], [[4qkl]], [[4qkm]], [[5joo]], [[5ttc]], [[5um1]], [[6mpl]], [[6mpm]], [[6mpn]] - IavM2 TM – Influenza A virus<br /> | |||
[[3lbw]], [[4rwb]], [[4rwc]], [[5c02]] – IavM2 TM (mutant) <br /> | |||
[[3c9j]], [[6bkk]], [[6bmz]] - IavM2 TM + amantadine derivative<br /> | |||
[[6oug]] - IavM2 TM (mutant) + amantadine derivative<br /> | |||
[[6bkl]], [[6boc]] - IavM2 TM + rimantadine<br /> | |||
[[2rlf]] - IavM2 TM +rimantadine - NMR<br /> | |||
[[1mp6]], [[1nyj]], [[2h95]], [[2kqt]] - IavM2 TM – NMR<br /> | |||
[[2kih]], [[2kwx]], [[2l0j]] - IavM2 TM (mutant) – NMR<br /> | |||
[[2ljb]], [[2ljc]] - IavM2 TM (mutant)/IbvM2 TM – NMR<br /> | |||
[[2kix]] - IbvM2 TM (mutant) – Influenza B virus – NMR<br /> | |||
[[2kj1]] – IbvM2 cytoplasmic domain - NMR<br /> | |||
[[4c3b]], [[4c3d]] – hrsvM2 – Human respiratory syncytial virus<br /> | |||
[[4c3e]] – hrsvM2 (mutant)<br /> | |||
[[5nkx]] – hrsvM2 core domain 73-185<br /> | |||
[[2l9j]] – hrsvM2 core domain (mutant) - NMR<br /> | |||
[[6g0y]] – hrsvM2 + phosphoprotein<br /> | |||
[[6pzq]] – hrsvM2 + RNA<br /> | |||
[[5hyu]] – M2 residues 42-142 + C4B-binding protein alpha chain – ''Steptococcus pyogenes''<br /> | |||
== References == | |||
<references/> | |||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
