1m63: Difference between revisions

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[[Image:1m63.png|left|200px]]


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==Crystal structure of calcineurin-cyclophilin-cyclosporin shows common but distinct recognition of immunophilin-drug complexes==
The line below this paragraph, containing "STRUCTURE_1m63", creates the "Structure Box" on the page.
<StructureSection load='1m63' size='340' side='right'caption='[[1m63]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[1m63]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Tolypocladium_inflatum Tolypocladium inflatum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M63 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1M63 FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ABA:ALPHA-AMINOBUTYRIC+ACID'>ABA</scene>, <scene name='pdbligand=BMT:4-METHYL-4-[(E)-2-BUTENYL]-4,N-METHYL-THREONINE'>BMT</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=DAL:D-ALANINE'>DAL</scene>, <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=MLE:N-METHYLLEUCINE'>MLE</scene>, <scene name='pdbligand=MVA:N-METHYLVALINE'>MVA</scene>, <scene name='pdbligand=SAR:SARCOSINE'>SAR</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
{{STRUCTURE_1m63|  PDB=1m63  |  SCENE=  }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1m63 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1m63 OCA], [https://pdbe.org/1m63 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1m63 RCSB], [https://www.ebi.ac.uk/pdbsum/1m63 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1m63 ProSAT]</span></td></tr>
 
</table>
===Crystal structure of calcineurin-cyclophilin-cyclosporin shows common but distinct recognition of immunophilin-drug complexes===
== Function ==
 
[https://www.uniprot.org/uniprot/PP2BA_HUMAN PP2BA_HUMAN] Calcium-dependent, calmodulin-stimulated protein phosphatase. This subunit may have a role in the calmodulin activation of calcineurin. Dephosphorylates DNM1L, HSPB1 and SSH1.<ref>PMID:15671020</ref> <ref>PMID:18838687</ref>
 
== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
The line below this paragraph, {{ABSTRACT_PUBMED_12218175}}, adds the Publication Abstract to the page
Check<jmol>
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    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/m6/1m63_consurf.spt"</scriptWhenChecked>
{{ABSTRACT_PUBMED_12218175}}
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    <text>to colour the structure by Evolutionary Conservation</text>
==About this Structure==
  </jmolCheckbox>
[[1m63]] is a 8 chain structure of [[Cyclophilin]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M63 OCA].  
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1m63 ConSurf].
<div style="clear:both"></div>


==See Also==
==See Also==
*[[Cyclophilin]]
*[[Calcineurin 3D structures|Calcineurin 3D structures]]
 
*[[Cyclophilin 3D structures|Cyclophilin 3D structures]]
==Reference==
== References ==
<ref group="xtra">PMID:012218175</ref><references group="xtra"/>
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Phosphoprotein phosphatase]]
[[Category: Large Structures]]
[[Category: Huai, Q.]]
[[Category: Tolypocladium inflatum]]
[[Category: Ke, H.]]
[[Category: Huai Q]]
[[Category: Kim, H Y.]]
[[Category: Ke H]]
[[Category: Liu, J O.]]
[[Category: Kim H-Y]]
[[Category: Liu, Y.]]
[[Category: Liu JO]]
[[Category: Mondragon, A.]]
[[Category: Liu Y]]
[[Category: Zhao, Y.]]
[[Category: Mondragon A]]
[[Category: Calcineurin]]
[[Category: Zhao Y]]
[[Category: Cyclophilin]]
[[Category: Cyclosporin some]]
[[Category: Hydrolase-isomerase-immunosuppressant complex]]
[[Category: Immunophilin]]
[[Category: Immunosuppressant]]

Latest revision as of 06:07, 3 April 2024

Crystal structure of calcineurin-cyclophilin-cyclosporin shows common but distinct recognition of immunophilin-drug complexes

1m63, resolution 2.80Å

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