3b29: Difference between revisions

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'''Unreleased structure'''


The entry 3b29 is ON HOLD
==Human leukotriene C4 synthase in complex with dodecyl-beta-D-selenomaltoside==
<StructureSection load='3b29' size='340' side='right'caption='[[3b29]], [[Resolution|resolution]] 3.20&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[3b29]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3B29 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3B29 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.2&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GSH:GLUTATHIONE'>GSH</scene>, <scene name='pdbligand=LSM:DODECYL+4-O-ALPHA-D-GLUCOPYRANOSYL-1-SELENO-BETA-D-GLUCOPYRANOSIDE'>LSM</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3b29 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3b29 OCA], [https://pdbe.org/3b29 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3b29 RCSB], [https://www.ebi.ac.uk/pdbsum/3b29 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3b29 ProSAT]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/LTC4S_HUMAN LTC4S_HUMAN] Defects in LTC4S are the cause of leukotriene C4 synthase deficiency (LTC4 synthase deficiency) [MIM:[https://omim.org/entry/246530 246530]. LTC4 synthase deficiency is a fatal neurometabolic developmental disorder. It is associated with muscular hypotonia, psychomotor retardation, failure to thrive, and microcephaly.
== Function ==
[https://www.uniprot.org/uniprot/LTC4S_HUMAN LTC4S_HUMAN] Catalyzes the conjugation of leukotriene A4 with reduced glutathione to form leukotriene C4.


Authors: Saino, H, Ago, H, Miyano, M
==See Also==
 
*[[Leukotriene C4 synthase|Leukotriene C4 synthase]]
Description: Human leukotriene C4 synthase in complex with dodecyl-beta-D-selenomaltoside
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Ago H]]
[[Category: Miyano M]]
[[Category: Saino H]]
Retrieved from "https://proteopedia.org/3b29"