Albumin: Difference between revisions

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~~{{STRUCTURE_1e7e| PDB~~=~~1e7e | SIZE~~=~~400| SCENE~~= |right~~|CAPTION~~=Human serum albumin ~~complexed with fatty acid,~~ [[~~1e7e~~]] }}

__TOC__

==Function==

'''Albumin''' (Alb) is water-soluble protein. Serum albumin (SA) is the most abundant blood plasma protein. SA serves as carrier of fatty acids, bilirubin, ions and drugs. For details on human serum albumin see [[User:Neeharika Pothuri/Human Serum Albumin]].

'''Albumin''' (Alb) is water-soluble protein. Serum albumin (SA) is the most abundant blood plasma protein. SA serves as carrier of fatty acids, bilirubin, ions and drugs. For details on human serum albumin see

*[[User:Neeharika Pothuri/Human Serum Albumin]]

*[[Molecular Playground/Human Serum Albumin]]

*[[STRUCTURE 1BM0]]

*[[Albumin (Hebrew)]].

== Investigation on the Site-Selective Binding of Bovine Serum Albumin by Erlotinib Hydrochloride <ref>doi 10.1080/07391102.2012.726532</ref>==

The binding mode of <scene name='Journal:JBSD:26/Cv/2'>erlotinib hydrochloride (ET)</scene>, a targeted anticancer drug, to <scene name='Journal:JBSD:26/Cv/8'>bovine serum albumin (BSA)</scene> was investigated through 1H NMR, spectroscopic, thermodynamic and molecular modeling methods. Each subdomain is marked with a different colour (red for subdomain IA; orange, IB; cyan, IIA; yellow, IIB; green, IIIA; darkmagenta, IIIB). From these methods, the binding parameters, binding site, binding distance, and conformational changes were obtained. Site marker competitive experiments demonstrated that the <scene name='Journal:JBSD:26/Cv/6'>binding site was located in the hydrophobic pocket of site I (subdomain IIA)</scene>. The docking modeling agreed with the results of the fluorescence and displacement experiments.

~~{{TOC limit|limit=2}}~~

== 3D Structures of albumin ==

[[Albumin 3D structures]]

== 3D Structures of albumin ==

</StructureSection>

'''References'''

[[Category:Topic Page]]

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-{{STRUCTURE_1e7e|  PDB=1e7e  | SIZE=400| SCENE= |right|CAPTION=Human serum albumin complexed with fatty acid, [[1e7e]] }}
+<StructureSection load='' size='350' side='right' scene='Journal:JBSD:26/Cv/7' caption='Human serum albumin (PDB code [[1bm0]])'>
+__TOC__
+==Function==
-'''Albumin''' (Alb) is water-soluble protein.  Serum albumin (SA) is the most abundant blood plasma protein.  SA serves as carrier of fatty acids, bilirubin, ions and drugs.  For details on human serum albumin see [[User:Neeharika Pothuri/Human Serum Albumin]].
+'''Albumin''' (Alb) is water-soluble protein.  Serum albumin (SA) is the most abundant blood plasma protein.  SA serves as carrier of fatty acids, bilirubin, ions and drugs.  For details on human serum albumin see<br />
+*[[User:Neeharika Pothuri/Human Serum Albumin]]<br />
+*[[Molecular Playground/Human Serum Albumin]]<br />
+*[[STRUCTURE 1BM0]]<br />
+*[[Albumin (Hebrew)]].
+==  Investigation on the Site-Selective Binding of Bovine Serum Albumin by Erlotinib Hydrochloride <ref>doi 10.1080/07391102.2012.726532</ref>==
+The binding mode of <scene name='Journal:JBSD:26/Cv/2'>erlotinib hydrochloride (ET)</scene>, a targeted anticancer drug, to <scene name='Journal:JBSD:26/Cv/8'>bovine serum albumin (BSA)</scene> was investigated through 1H NMR, spectroscopic, thermodynamic and molecular modeling methods. Each subdomain is marked with a different colour (<font color='red'><b>red for subdomain IA</b></font>; <span style="color:orange;background-color:black;font-weight:bold;">orange, IB</span>; <span style="color:cyan;background-color:black;font-weight:bold;">cyan, IIA</span>; <span style="color:yellow;background-color:black;font-weight:bold;">yellow, IIB</span>; <span style="color:lime;background-color:black;font-weight:bold;">green, IIIA</span>; <font color='darkmagenta'><b>darkmagenta, IIIB</b></font>). From these methods, the binding parameters, binding site, binding distance, and conformational changes were obtained. Site marker competitive experiments demonstrated that the <scene name='Journal:JBSD:26/Cv/6'>binding site was located in the hydrophobic pocket of site I (subdomain IIA)</scene>. The docking modeling agreed with the results of the fluorescence and displacement experiments.
-{{TOC limit|limit=2}}
+== 3D Structures of albumin ==
+[[Albumin 3D structures]]
-== 3D Structures of albumin ==
+</StructureSection>
+'''References'''
+<references/>
 [[Category:Topic Page]]