2p7t: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older edit
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,331,613 edits
m Protected "2p7t" [edit=sysop:move=sysop]
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,331,613 edits
No edit summary
 
(8 intermediate revisions by the same user not shown)
Line 1: Line 1:
[[Image:2p7t.png|left|200px]]


<!--
==Crystal Structure of KcsA mutant==
The line below this paragraph, containing "STRUCTURE_2p7t", creates the "Structure Box" on the page.
<StructureSection load='2p7t' size='340' side='right'caption='[[2p7t]], [[Resolution|resolution]] 2.05&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[2p7t]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [https://en.wikipedia.org/wiki/Streptomyces_lividans Streptomyces lividans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2P7T OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2P7T FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.05&#8491;</td></tr>
-->
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1EM:(1S)-2-HYDROXY-1-[(NONANOYLOXY)METHYL]ETHYL+MYRISTATE'>1EM</scene>, <scene name='pdbligand=F09:NONAN-1-OL'>F09</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene></td></tr>
{{STRUCTURE_2p7t|  PDB=2p7t  |  SCENE=  }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2p7t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2p7t OCA], [https://pdbe.org/2p7t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2p7t RCSB], [https://www.ebi.ac.uk/pdbsum/2p7t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2p7t ProSAT]</span></td></tr>
 
</table>
===Crystal Structure of KcsA mutant===
== Function ==
 
[https://www.uniprot.org/uniprot/KCSA_STRLI KCSA_STRLI] Acts as a pH-gated potassium ion channel; changing the cytosolic pH from 7 to 4 opens the channel, although it is not clear if this is the physiological stimulus for channel opening. Monovalent cation preference is K(+) > Rb(+) > NH4(+) >> Na(+) > Li(+).<ref>PMID:7489706</ref>
 
== Evolutionary Conservation ==
<!--
[[Image:Consurf_key_small.gif|200px|right]]
The line below this paragraph, {{ABSTRACT_PUBMED_017922012}}, adds the Publication Abstract to the page
Check<jmol>
(as it appears on PubMed at http://www.pubmed.gov), where 017922012 is the PubMed ID number.
  <jmolCheckbox>
-->
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/p7/2p7t_consurf.spt"</scriptWhenChecked>
{{ABSTRACT_PUBMED_017922012}}
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
 
    <text>to colour the structure by Evolutionary Conservation</text>
==About this Structure==
  </jmolCheckbox>
[[2p7t]] is a 3 chain structure of [[Monoclonal Antibody]] and [[Potassium Channel]] with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [http://en.wikipedia.org/wiki/Streptomyces_lividans Streptomyces lividans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2P7T OCA].  
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2p7t ConSurf].
<div style="clear:both"></div>


==See Also==
==See Also==
*[[Monoclonal Antibody]]
*[[Antibody 3D structures|Antibody 3D structures]]
*[[Potassium Channel]]
*[[Potassium channel 3D structures|Potassium channel 3D structures]]
 
*[[3D structures of non-human antibody|3D structures of non-human antibody]]
==Reference==
== References ==
<ref group="xtra">PMID:017922012</ref><references group="xtra"/>
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
[[Category: Streptomyces lividans]]
[[Category: Streptomyces lividans]]
[[Category: Cordero-Morales, J F.]]
[[Category: Cordero-Morales JF]]
[[Category: Cortes, D M.]]
[[Category: Cortes DM]]
[[Category: Lewis, A.]]
[[Category: Lewis A]]
[[Category: Perozo, E.]]
[[Category: Perozo E]]
[[Category: Roux, B.]]
[[Category: Roux B]]
[[Category: Valeria, V R.]]
[[Category: Valeria VR]]
[[Category: Vishwanath, J.]]
[[Category: Vishwanath J]]
[[Category: Kcsa]]
[[Category: Membrane protein]]

Latest revision as of 01:18, 21 November 2024

Crystal Structure of KcsA mutant

2p7t, resolution 2.05Å

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "https://proteopedia.org/index.php?title=2p7t&oldid=4270740"