3t7a: Difference between revisions

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~~'''Unreleased structure'''~~

~~The entry~~ 3t7a is ~~ON HOLD~~

==Crystal structure of the catalytic domain of human diphosphoinositol pentakisphosphate kinase 2 (PPIP5K2) in complex with ADP at pH 5.2==

~~Authors~~: ~~Wang~~, H., ~~Falck~~, J., ~~Hall~~, T.M.T., ~~Shears, S~~.B.

== Structural highlights ==

<table><tr><td colspan='2'>[[3t7a]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3T7A OCA]. For a guided tour on the structure components use [https://proteopedia.org/fgij/fg.htm?mol=3T7A FirstGlance].

~~Description~~: ~~Crystal structure of~~ the ~~catalytic domain~~ of ~~PPIP5K2~~ in ~~complex with ADP~~ at ~~PH5~~.2

</td></tr><tr id='method'><td class="sblockLbl">[[Empirical_models|Method:]]</td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7Å</td></tr>

<tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[https://proteopedia.org/fgij/fg.htm?mol=3t7a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3t7a OCA], [https://pdbe.org/3t7a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3t7a RCSB], [https://www.ebi.ac.uk/pdbsum/3t7a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3t7a ProSAT]</td></tr>

</table>

== Function ==

[https://www.uniprot.org/uniprot/VIP2_HUMAN VIP2_HUMAN] Bifunctional inositol kinase that acts in concert with the IP6K kinases IP6K1, IP6K2 and IP6K3 to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, exocytosis, insulin signaling and neutrophil activation. Phosphorylates inositol hexakisphosphate (InsP6) at positions 1 or 3 to produce PP-InsP5 which is in turn phosphorylated by IP6Ks to produce (PP)2-InsP4. Alternatively, phosphorylates at position 1 or 3 PP-InsP5, produced by IP6Ks from InsP6, to produce (PP)2-InsP4.<ref>PMID:17690096</ref> <ref>PMID:17702752</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Homo sapiens]]

[[Category: Large Structures]]

[[Category: Falck J]]

[[Category: Hall TMT]]

[[Category: Shears SB]]

[[Category: Wang H]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 3t7a is ON HOLD
+==Crystal structure of the catalytic domain of human diphosphoinositol pentakisphosphate kinase 2 (PPIP5K2) in complex with ADP at pH 5.2==
+<StructureSection load='3t7a' size='340' side='right'caption='[[3t7a]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
-Authors: Wang, H., Falck, J., Hall, T.M.T., Shears, S.B.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[3t7a]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3T7A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3T7A FirstGlance]. <br>
-Description: Crystal structure of the catalytic domain of PPIP5K2 in complex with ADP at PH5.2
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3t7a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3t7a OCA], [https://pdbe.org/3t7a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3t7a RCSB], [https://www.ebi.ac.uk/pdbsum/3t7a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3t7a ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/VIP2_HUMAN VIP2_HUMAN] Bifunctional inositol kinase that acts in concert with the IP6K kinases IP6K1, IP6K2 and IP6K3 to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, exocytosis, insulin signaling and neutrophil activation. Phosphorylates inositol hexakisphosphate (InsP6) at positions 1 or 3 to produce PP-InsP5 which is in turn phosphorylated by IP6Ks to produce (PP)2-InsP4. Alternatively, phosphorylates at position 1 or 3 PP-InsP5, produced by IP6Ks from InsP6, to produce (PP)2-InsP4.<ref>PMID:17690096</ref> <ref>PMID:17702752</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Homo sapiens]]
+[[Category: Large Structures]]
+[[Category: Falck J]]
+[[Category: Hall TMT]]
+[[Category: Shears SB]]
+[[Category: Wang H]]