3t7t: Difference between revisions
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New page: '''Unreleased structure''' The entry 3t7t is ON HOLD Authors: V. Kumar, J. Sivaraman Description: Crystal structure of complex of SAM BVU_3255 and SAM, a methyltransferase from Bactero... |
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The | ==Crystal structure of complex of SAH and BVU_3255, a methyltransferase from Bacteroides vulgatus ATCC 8482== | ||
<StructureSection load='3t7t' size='340' side='right'caption='[[3t7t]], [[Resolution|resolution]] 2.50Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[3t7t]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Phocaeicola_vulgatus_ATCC_8482 Phocaeicola vulgatus ATCC 8482]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3T7T OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3T7T FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3t7t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3t7t OCA], [https://pdbe.org/3t7t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3t7t RCSB], [https://www.ebi.ac.uk/pdbsum/3t7t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3t7t ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/A6L5C0_PHOV8 A6L5C0_PHOV8] | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
Methylation is important for various cellular activities. To date, there is no report of any methyltransferase structure from the human intestine antibiotic resistant pathogen Bacteroides vulgatus. The protein BVU_3255 from B. vulgatus ATCC 8482 belongs to a SAM-dependent methyltransferase. Here, we report the crystal structure of apo BVU_3255, and its complexes with SAM and SAH, which revealed a typical class I Rossmann Fold Methyltransferase. Isothermal titration calorimetric studies showed that both SAM and SAH bind with equal affinity. The structural and sequence analysis suggested that BVU_3255 is a small molecule methyltransferase and involved in methylating the intermediates in ubiquinone biosynthesis pathway. | |||
Structural characterization of BVU_3255, a methyltransferase from human intestine antibiotic resistant pathogen Bacteroides vulgatus.,Kumar V, Sivaraman J J Struct Biol. 2011 Aug 22. PMID:21872662<ref>PMID:21872662</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
</div> | |||
<div class="pdbe-citations 3t7t" style="background-color:#fffaf0;"></div> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Phocaeicola vulgatus ATCC 8482]] | |||
[[Category: Kumar V]] | |||
[[Category: Sivaraman J]] | |||
Latest revision as of 17:29, 1 November 2023
Crystal structure of complex of SAH and BVU_3255, a methyltransferase from Bacteroides vulgatus ATCC 8482
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