3t8v: Difference between revisions
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New page: '''Unreleased structure''' The entry 3t8v is ON HOLD Authors: McGowan, S., Klemba, M., Greebaum, D.C. Description: A bestatin-based chemical biology strategy reveals distinct roles for... |
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==A bestatin-based chemical biology strategy reveals distinct roles for malaria M1- and M17-family aminopeptidases== | |||
<StructureSection load='3t8v' size='340' side='right'caption='[[3t8v]], [[Resolution|resolution]] 1.80Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[3t8v]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Plasmodium_falciparum_FcB1/Columbia Plasmodium falciparum FcB1/Columbia]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3T8V OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3T8V FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BTJ:N-[(2-{2-[(N-{(2S,3R)-3-AMINO-4-[4-(BENZYLOXY)PHENYL]-2-HYDROXYBUTANOYL}-L-ALANYL)AMINO]ETHOXY}ETHOXY)ACETYL]-4-BENZOYL-L-PHENYLALANYL-N~6~-HEX-5-YNOYLLYSINAMIDE'>BTJ</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3t8v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3t8v OCA], [https://pdbe.org/3t8v PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3t8v RCSB], [https://www.ebi.ac.uk/pdbsum/3t8v PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3t8v ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/AMP1_PLAFQ AMP1_PLAFQ] Displays aminopeptidase activity with a broad substrate specificity. Preferentially hydrolyzes L-Lys-AMC but also shows strong activity against L-Ala-AMC, L-Arg-AMC and L-Leu-AMC.<ref>PMID:12166515</ref> <ref>PMID:19196988</ref> | |||
==See Also== | |||
*[[Aminopeptidase 3D structures|Aminopeptidase 3D structures]] | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Plasmodium falciparum FcB1/Columbia]] | |||
[[Category: Greebaum DC]] | |||
[[Category: Klemba M]] | |||
[[Category: McGowan S]] | |||
