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New page: left|200px<br /><applet load="2oxk" size="350" color="white" frame="true" align="right" spinBox="true" caption="2oxk, resolution 2.00Å" /> '''Helix Bundle Quatern...
 
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[[Image:2oxk.jpg|left|200px]]<br /><applet load="2oxk" size="350" color="white" frame="true" align="right" spinBox="true"
caption="2oxk, resolution 2.00&Aring;" />
'''Helix Bundle Quaternary Structure from alpha/beta-Peptide Foldamers: GCN4-pLI with beta-residues at b and f heptad positions.'''<br />


==Overview==
==Helix Bundle Quaternary Structure from alpha/beta-Peptide Foldamers: GCN4-pLI with beta-residues at b and f heptad positions.==
The function of a protein generally depends on adoption of a specific, folding pattern, which in turn is determined by the side chain sequence, along the polypeptide backbone. Here we show that the sequence-encoded, structural information in peptides derived from yeast transcriptional, activator GCN4 can be used to prepare hybrid alpha/beta-peptide foldamers, that adopt helix bundle quaternary structures. Crystal structures of two, hybrid alpha/beta-peptides are reported along with detailed structural, comparison to alpha-peptides of analogous side chain sequence. There is, considerable homology between alpha- and alpha/beta-peptides at the level, of helical secondary structure, with modest but significant differences in, the association geometry of helices in the quaternary structure.
<StructureSection load='2oxk' size='340' side='right'caption='[[2oxk]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2oxk]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OXK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2OXK FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=B3A:(3S)-3-AMINOBUTANOIC+ACID'>B3A</scene>, <scene name='pdbligand=B3D:3-AMINOPENTANEDIOIC+ACID'>B3D</scene>, <scene name='pdbligand=B3E:(3S)-3-AMINOHEXANEDIOIC+ACID'>B3E</scene>, <scene name='pdbligand=B3K:(3S)-3,7-DIAMINOHEPTANOIC+ACID'>B3K</scene>, <scene name='pdbligand=B3S:(3R)-3-AMINO-4-HYDROXYBUTANOIC+ACID'>B3S</scene>, <scene name='pdbligand=B3X:(3S)-3,5-DIAMINO-5-OXOPENTANOIC+ACID'>B3X</scene>, <scene name='pdbligand=B3Y:(3S)-3-AMINO-4-(4-HYDROXYPHENYL)BUTANOIC+ACID'>B3Y</scene>, <scene name='pdbligand=BAL:BETA-ALANINE'>BAL</scene>, <scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2oxk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2oxk OCA], [https://pdbe.org/2oxk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2oxk RCSB], [https://www.ebi.ac.uk/pdbsum/2oxk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2oxk ProSAT]</span></td></tr>
</table>


==About this Structure==
==See Also==
2OXK is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/ ] with <scene name='pdbligand=FMT:'>FMT</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OXK OCA].
*[[Gcn4 3D Structures|Gcn4 3D Structures]]
 
*[[Gnc4 3D Structures|Gnc4 3D Structures]]
==Reference==
__TOC__
Helix Bundle Quaternary Structure from alpha/beta-Peptide Foldamers., Horne WS, Price JL, Keck JL, Gellman SH, J Am Chem Soc. 2007 Apr 11;129(14):4178-80. Epub 2007 Mar 16. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=17362016 17362016]
</StructureSection>
[[Category: Protein complex]]
[[Category: Large Structures]]
[[Category: Gellman, S.H.]]
[[Category: Gellman SH]]
[[Category: Horne, W.S.]]
[[Category: Horne WS]]
[[Category: Keck, J.L.]]
[[Category: Keck JL]]
[[Category: Price, J.L.]]
[[Category: Price JL]]
[[Category: FMT]]
[[Category: coiled coil]]
[[Category: foldamer]]
[[Category: helix bundle]]
 
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