3te3: Difference between revisions
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New page: '''Unreleased structure''' The entry 3te3 is ON HOLD Authors: Yernool, D. A., Molland, K.M Description: Coiled-coil oligomerization domain of the polycystin transient receptor potentia... |
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==Coiled-coil oligomerization domain of the polycystin transient receptor potential channel PKD2L1== | |||
<StructureSection load='3te3' size='340' side='right'caption='[[3te3]], [[Resolution|resolution]] 2.69Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[3te3]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TE3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3TE3 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.694Å</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3te3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3te3 OCA], [https://pdbe.org/3te3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3te3 RCSB], [https://www.ebi.ac.uk/pdbsum/3te3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3te3 ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/PK2L1_HUMAN PK2L1_HUMAN] Pore-forming subunit of a ciliary calcium channel that controls calcium concentration within primary cilia without affecting cytoplasmic calcium concentration. Forms a heterodimer with PKD1L1 in primary cilia and forms a calcium-permeant ciliary channel that regulates sonic hedgehog/SHH signaling and GLI2 transcription. May act as a sour taste receptor by forming a calcium channel with PKD1L3 in gustatory cells; however, its contribution to sour taste perception is unclear in vivo and may be indirect.<ref>PMID:10517637</ref> <ref>PMID:19812697</ref> <ref>PMID:23212381</ref> <ref>PMID:24336289</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Molland KM]] | |||
[[Category: Yernool DA]] | |||
