Pre-mRNA-splicing factor: Difference between revisions
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Michal Harel (talk | contribs) New page: {{STRUCTURE_3e9l| PDB=3e9l | SIZE=400| SCENE= |right|CAPTION=Human pre-mRNA-splicing factor 8 endonuclease domain, 3e9l }} '''Pre-mRNA-splicing factors (Prp)''' are the proteins whi... |
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<StructureSection load='' size='350' side='right' caption='Yeast pre-mRNA-splicing factor 8 (green) complex with AAR2 (cyan) (PDB entry [[3zef]])' scene='46/462200/Cv/1'> | |||
__TOC__ | |||
== Function == | |||
'''Pre-mRNA-splicing factors (Prp)''' are the proteins which associate with mRNA at its various splicing sites to produce alternative splicing<ref>PMID:10394358</ref>. | |||
''' | *'''Prp3b''' is part of the U2 small nuclear ribonucleoproteins complex (U2 snRNP)<br /> | ||
*'''Prp8''' functions as a scaffold which mediates the ordered assembly of spliceosomal proteins and snRNAs. For details see [[Prp8]]<br /> | |||
*'''Prp18''' and '''Bud31''' are essential for the catalytic step in pre-mRNA splicing process.<br /> | |||
*'''snRNA-associated-splicing factor 24''' binds preferentially to the U4/U6 hybrid snRNAs. For details see [[Prp24]]<br /> | |||
*For '''Prp19''' see [[Prp19]]<br /> | |||
*For '''Prp20''' see [[Srp20-Human Alternative Splicing Factor]]<br /> | |||
*'''Prp31''' functions in forming the U4/U5-U6 tri-snRNP.<br /> | |||
*For '''Prp40''' see [[Prp40]].<br /> | |||
*'''Prpcwc2''' is a yeast splicing factor which plays a role in the generation of a functional splicing center '''Prp RBM22''' is the human homolog of Prpcwc2.<br /> | |||
*'''Prpcwc26''' or '''Bud13''' belongs to the pre-mRNA retention and splicing complex RES.<br /> | |||
== Disease == | |||
Mutations in Prp8 and Prp31 cause retinitis pigmentosa<ref>PMID:11468273</ref>. | |||
== Structural highlights == | |||
<scene name='46/462200/Cv/3'>Prp8 is a multi-domain protein containing an RNA-binding domain and a Jab1/MPN domain</scene>. | |||
== 3D Structures of pre-mRNA splicing factors == | == 3D Structures of pre-mRNA splicing factors == | ||
[[Pre-mRNA splicing factors 3D structures]] | |||
</StructureSection> | |||
== References == | |||
<references/> | |||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
