Pre-mRNA-splicing factor

spinqualitylabelsall models Yeast pre-mRNA-splicing factor 8 (green) complex with AAR2 (cyan) (PDB entry 3zef) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Pre-mRNA-splicing factors (Prp) are the proteins which associate with mRNA at its various splicing sites to produce alternative splicing. Prp3b is part of the U2 small nuclear ribonucleoproteins complex (U2 snRNP) Prp8 functions as a scaffold which mediates the ordered assembly of spliceosomal proteins and snRNAs. For details see Prp8 Prp18 and Bud31 are essential for the catalytic step in pre-mRNA splicing process. snRNA-associated-splicing factor 24 binds preferentially to the U4/U6 hybrid snRNAs. For details see Prp24 For Prp19 see Prp19 For Prp20 see Srp20-Human Alternative Splicing Factor Prp31 functions in forming the U4/U5-U6 tri-snRNP. For Prp40 see Prp40. Prpcwc2 is a yeast splicing factor which plays a role in the generation of a functional splicing center Prp RBM22 is the human homolog of Prpcwc2. Prpcwc26 or Bud13 belongs to the pre-mRNA retention and splicing complex RES. Disease Mutations in Prp8 and Prp31 cause retinitis pigmentosa. Structural highlights Prp8 is a multi-domain protein containing an RNA-binding domain and a Jab1/MPN domain. 3D Structures of pre-mRNA splicing factors Pre-mRNA splicing factors 3D structures

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