2wfl: Difference between revisions

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[[Image:2wfl.png|left|200px]]


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==Crystal structure of polyneuridine aldehyde esterase==
The line below this paragraph, containing "STRUCTURE_2wfl", creates the "Structure Box" on the page.
<StructureSection load='2wfl' size='340' side='right'caption='[[2wfl]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[2wfl]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Rauvolfia_serpentina Rauvolfia serpentina]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WFL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WFL FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CME:S,S-(2-HYDROXYETHYL)THIOCYSTEINE'>CME</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
{{STRUCTURE_2wfl|  PDB=2wfl  |  SCENE=  }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2wfl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wfl OCA], [https://pdbe.org/2wfl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2wfl RCSB], [https://www.ebi.ac.uk/pdbsum/2wfl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2wfl ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/PNAE_RAUSE PNAE_RAUSE] Catalyzes the hydrolysis of polyneuridine aldehyde into epi-vellosimine, which is the immediate precursor for the synthesis of the ajmaline.<ref>PMID:10691977</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wf/2wfl_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2wfl ConSurf].
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Cutting carbons: The three-dimensional structure of polyneuridine aldehyde esterase (PNAE) gives insight into the enzymatic mechanism of the biosynthesis of C(9)- from C(10)-monoterpenoid indole alkaloids (see scheme). PNAE is a very substrate-specific serine esterase. It harbors the catalytic triad S87-D216-H244, and is a new member of the alpha/beta-fold hydrolase superfamily. Its novel function leads to the diversification of alkaloid structures.


===CRYSTAL STRUCTURE OF POLYNEURIDINE ALDEHYDE ESTERASE===
Structural basis and enzymatic mechanism of the biosynthesis of C9- from C10-monoterpenoid indole alkaloids.,Yang L, Hill M, Wang M, Panjikar S, Stockigt J Angew Chem Int Ed Engl. 2009;48(28):5211-3. PMID:19496101<ref>PMID:19496101</ref>


 
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
The line below this paragraph, {{ABSTRACT_PUBMED_19496101}}, adds the Publication Abstract to the page
<div class="pdbe-citations 2wfl" style="background-color:#fffaf0;"></div>
(as it appears on PubMed at http://www.pubmed.gov), where 19496101 is the PubMed ID number.
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{{ABSTRACT_PUBMED_19496101}}
 
==About this Structure==
[[2wfl]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Rauvolfia_serpentina Rauvolfia serpentina]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WFL OCA].


==See Also==
==See Also==
*[[Polyneuridine Aldehyde Esterase]]
*[[Polyneuridine Aldehyde Esterase|Polyneuridine Aldehyde Esterase]]
 
== References ==
==Reference==
<references/>
<ref group="xtra">PMID:019496101</ref><references group="xtra"/>
__TOC__
[[Category: Polyneuridine-aldehyde esterase]]
</StructureSection>
[[Category: Large Structures]]
[[Category: Rauvolfia serpentina]]
[[Category: Rauvolfia serpentina]]
[[Category: Hill, M.]]
[[Category: Hill M]]
[[Category: Panjikar, S.]]
[[Category: Panjikar S]]
[[Category: Stoeckigt, J.]]
[[Category: Stoeckigt J]]
[[Category: Wang, M.]]
[[Category: Wang M]]
[[Category: Yang, L.]]
[[Category: Yang L]]
[[Category: Alkaloid metabolism]]
[[Category: Hydrolase]]
[[Category: Monoterpenoid indole alkaloid]]
[[Category: Pnae]]
[[Category: Serine esterase]]

Latest revision as of 15:54, 13 December 2023

Crystal structure of polyneuridine aldehyde esterase

2wfl, resolution 2.10Å

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