2w1z: Difference between revisions
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< | ==ROP2 from Toxoplasma gondii: A virulence factor with a protein- kinase fold and no enzymatic activity.== | ||
<StructureSection load='2w1z' size='340' side='right'caption='[[2w1z]], [[Resolution|resolution]] 1.97Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[2w1z]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Toxoplasma_gondii_RH Toxoplasma gondii RH]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W1Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2W1Z FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.97Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2w1z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w1z OCA], [https://pdbe.org/2w1z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2w1z RCSB], [https://www.ebi.ac.uk/pdbsum/2w1z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2w1z ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/Q27007_TOXGO Q27007_TOXGO] | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
The ROP2 protein and its paralogs are important virulence factors secreted into the host cell by the parasite Toxoplasma gondii. Here we describe the crystal structure of a large and soluble domain of mature ROP2, representative of the ROP2-like protein family. This is a structure of a protein-kinase fold that is devoid of catalytic residues and does not bind ATP. Various structural extensions constitute a signature of this protein family and act to maintain the protein kinase in an open conformation. Our ROP2 structure rules out a previous structural model of attachment of ROP2-like proteins to the parasitophorous vacuole membrane. We propose an alternative mode of membrane attachment implicating basic and amphiphatic helices present in the flexible N terminus of ROP2. | |||
ROP2 from Toxoplasma gondii: a virulence factor with a protein-kinase fold and no enzymatic activity.,Labesse G, Gelin M, Bessin Y, Lebrun M, Papoin J, Cerdan R, Arold ST, Dubremetz JF Structure. 2009 Jan 14;17(1):139-46. PMID:19141290<ref>PMID:19141290</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
</div> | |||
<div class="pdbe-citations 2w1z" style="background-color:#fffaf0;"></div> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
== | [[Category: Large Structures]] | ||
[[Category: Toxoplasma gondii RH]] | |||
[[Category: Arold ST]] | |||
== | [[Category: Bessin Y]] | ||
< | [[Category: Dubremetz J-F]] | ||
[[Category: Toxoplasma gondii]] | [[Category: Gelin M]] | ||
[[Category: Arold | [[Category: Labesse G]] | ||
[[Category: Bessin | [[Category: Lebrun M]] | ||
[[Category: Dubremetz | |||
[[Category: Gelin | |||
[[Category: Labesse | |||
[[Category: Lebrun | |||
Latest revision as of 11:17, 3 January 2024
ROP2 from Toxoplasma gondii: A virulence factor with a protein- kinase fold and no enzymatic activity.
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