3zxs: Difference between revisions
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New page: '''Unreleased structure''' The entry 3zxs is ON HOLD Authors: Geisselbrecht, Y., Fruhwirth, S., Pierik, A., Klug, G., Essen, L.-O. Description: Cryptochrome B from Rhodobacter sphaeroi... |
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The | ==Cryptochrome B from Rhodobacter sphaeroides== | ||
<StructureSection load='3zxs' size='340' side='right'caption='[[3zxs]], [[Resolution|resolution]] 2.70Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[3zxs]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Cereibacter_sphaeroides_2.4.1 Cereibacter sphaeroides 2.4.1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZXS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ZXS FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DLZ:1-DEOXY-1-(6,7-DIMETHYL-2,4-DIOXO-3,4-DIHYDROPTERIDIN-8(2H)-YL)-D-RIBITOL'>DLZ</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=GD:GADOLINIUM+ATOM'>GD</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3zxs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zxs OCA], [https://pdbe.org/3zxs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3zxs RCSB], [https://www.ebi.ac.uk/pdbsum/3zxs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3zxs ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/Q3IXP1_CERS4 Q3IXP1_CERS4] | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
Cryptochromes and photolyases are structurally related but have different biological functions in signalling and DNA repair. Proteobacteria and cyanobacteria harbour a new class of cryptochromes, called CryPro. We have solved the 2.7 A structure of one of its members, cryptochrome B from Rhodobacter sphaeroides, which is a regulator of photosynthesis gene expression. The structure reveals that, in addition to the photolyase-like fold, CryB contains two cofactors only conserved in the CryPro subfamily: 6,7-dimethyl-8-ribityl-lumazine in the antenna-binding domain and a [4Fe-4S] cluster within the catalytic domain. The latter closely resembles the iron-sulphur cluster harbouring the large primase subunit PriL, indicating that PriL is evolutionarily related to the CryPro class of cryptochromes. | |||
CryB from Rhodobacter sphaeroides: a unique class of cryptochromes with new cofactors.,Geisselbrecht Y, Fruhwirth S, Schroeder C, Pierik AJ, Klug G, Essen LO EMBO Rep. 2012 Jan 31. doi: 10.1038/embor.2012.2. PMID:22290493<ref>PMID:22290493</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
</div> | |||
<div class="pdbe-citations 3zxs" style="background-color:#fffaf0;"></div> | |||
==See Also== | |||
*[[Cryptochrome 3D structures|Cryptochrome 3D structures]] | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Cereibacter sphaeroides 2 4.1]] | |||
[[Category: Large Structures]] | |||
[[Category: Essen L-O]] | |||
[[Category: Fruhwirth S]] | |||
[[Category: Geisselbrecht Y]] | |||
[[Category: Klug G]] | |||
[[Category: Pierik AJ]] | |||
Latest revision as of 17:53, 8 September 2026
Cryptochrome B from Rhodobacter sphaeroides
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